Synthesis of acridinyl-thiazolino derivatives and their evaluation for anti-inflammatory, analgesic and kinase inhibition activities

Ruthenium (II) complexes containing 2-mercaptothiazolinates as ligands and evaluation of their antimicrobial activity

“…Noteworthy is the route for the synthesis of racemic cysteine introduced by Degussa AG, in which the key intermediate is the 2,2-dimethyl-3-thiazoline [35]. Thiazolines are also important due to their activity against several life threatening infections or diseases, including antimicrobial [36], anti-inflammatory [37], anticancer [38], anti-oxidant [39] and antimycobacterium [40] activities.…”

Design and synthesis of positional isomers of 5 and 6-bromo-1-[(phenyl)sulfonyl]-2-[(4-nitrophenoxy)methyl]-1H-benzimidazoles as possible antimicrobial and antitubercular agents

“…Benzimidazole and its derivatives are reported to be physiologically and pharmacologically active and find applications in the treatment of several diseases like epilepsy, diabetes, antifertility. 10,11 It is an important pharmacophore and privileged structure in medicinal chemistry 12,13 encompassing a diverse range of biological activities including antibacterial, 14 antiinflammatory, analgesic, 15,16 antihistamine, 17 antiulcerative, 18 antioxidant, 19 antiproliferative, 20,21 antiallergic, 22,23 antitumor, 24,25 antikinase, 26,27 anticancer activities, 28-32 cytotoxicity, 33 and anti-HIV-1. 34,35 Owing to the importance of benzimidazole, now we wish to describe the SAR studies of regioisomers of benzimidazole and their in vitro screening results of antimicrobial and antitubercular activities.…”

Anti-Proliferation Effects of Benzimidazole Derivatives on HCT-116 Colon Cancer and MCF-7 Breast Cancer Cell Lines

“…In other studies, they also can act as antibacterial agent (Nezhad et al, 2005;Ozden et al, 2005), and showed anthelmintics activity of Trichinella spiralis (Mavrova et al, 2005), anti-inflammatory and analgesic activities (Sondhi et al, 2006) and as inhibitors for the hepatitis B (Li et al, 2006) and C viruses (Beaulieu et al, 2004). Some benzimidazoles were also tested as anti-HIV (Roth et al, 1997;Smith et al, 2003), anticancer agents (Craigo et al, 1999;Rida et al, 2006) and antioxidants (Kus et al, 2008).…”