Synthesis of a Series of Quinoline-Based New Chiral Reagent and its Application in Separation of Racemic Mexiletine followed by Liquid Chromatography and Confirmation of Results Using Molecular Modelling; A Complete Study
M. Solanki,
S. Sehlangia,
V.S. Talismanov
et al.
Abstract:In present work, L-valine-based new chiral derivatives were prepared by introducing hydrophobic groups. The prepared derivatives were then used to prepare quinoline-based chiral reagents under mild amidation reaction and esterification reaction. Spectroscopic techniques, such as HRMS, FT-IR, 1H NMR and CHNS analysis, were used to characterize the synthesized chiral reagents. The synthesized series of reagents was then used to derivatize diastereomers of racemic mexiletine and these diastereomers were separa… Show more
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