Synthesis of a Ruthenium(II) Compound based on 5‐(2‐Pyrimidyl)‐1H‐tetrazole for Photodynamic Therapy

Wei, Bo; Guo, Meng; Lu, Yi Ming; Sun, Peng; Gao, Yang; Li, Qiao Yun

doi:10.1002/zaac.201700343

Cited by 10 publications

(1 citation statement)

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“…[ 35 ] We found a very low IC 50 of around 23 μg mL −1 for the ND−NG−Ru (Figure 4D), which is similar to the reported IC 50 of 15 μg mL −1 of the Ru−tetrazole‐coordinated nanoparticles. [ 36 ] Live/dead staining of the cells using fluorescein diacetate/propidium iodide further demonstrated that ND−NG−Ru‐induced cell death upon irradiation could be spatially controlled (Figure 4F). Furthermore, we confirmed induced cell death using Annexin‐V, a protein that binds to phosphatidylserine, which is only present during apoptosis (Figure 4G).…”

Section: Resultsmentioning

confidence: 98%

Fluorescent Nanodiamond–Nanogels for Nanoscale Sensing and Photodynamic Applications

Alam

Balasubramanian

et al. 2021

Advanced NanoBiomed Research

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Fluorescent nanodiamonds (NDs) are carbon‐based nanoparticles with various outstanding magneto−optical properties. After preparation, NDs have a variety of different surface groups that determine their physicochemical properties. For biological applications, surface modifications are crucial to impart a new interface for controlled interactions with biomolecules or cells. Herein, a straightforward synthesis concept denoted “adsorption−crosslinking” is applied for the efficient modification of NDs, which sequentially combines fast noncovalent adsorption based on electrostatic interactions and subsequent covalent crosslinking. As a result, a very thin and uniform nanogel (NG) coating surrounding the NDs is obtained, which imparts reactive groups as well as high colloidal stability. The impact of the reaction time, monomer concentration, molecular weight, structure of the crosslinker on the resulting NG shell, the availability of reactive chemical surface functions, and the quantum sensing properties of the coated NDs are assessed and optimized. Postmodification of the NG‐coated NDs is achieved with phototoxic ruthenium complexes yielding ND‐based probes suitable for photodynamic applications. The adsorption−crosslinking ND functionalization reported herein provides new avenues toward functional probes and traceable nanocarriers for high‐resolution bioimaging, nanoscale sensing, and photodynamic applications.

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Section: Resultsmentioning

confidence: 98%