Synthesis of a ruthenium(II) bipyridyl complex coordinated by a functionalized Schiff base ligand: Characterization, spectroscopic and isothermal titration calorimetry measurements of M2+ binding and sensing (M2+=Ca2+, Mg2+)

Dixit, N.N.; Mishra, Lallan; Mustafi, Sourajit M.; Chary, Kandala V. R.; Houjou, Hirohiko

doi:10.1016/j.saa.2009.01.015

Cited by 14 publications

(7 citation statements)

References 17 publications

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“…In 2009 we identified more than 400 articles after searching Web of Science, PubMed, SciDir and OVID databases using ‘isothermal AND titration AND calorimetry’ or ITC or ‘Isothermal Titration Calorimetry’ search terms. These have been classified into the following categories: Pre‐2009 references cited in the text and review articles 1–43 Protein‐protein and protein‐peptide interactions 44–124 Protein/peptide‐small molecule interactions 125–218 Protein/peptide‐metal ion interactions 219–253 Protein/peptide‐nucleic acid interactions 254–273 Protein/peptide‐lipid interactions 274–292 Protein/peptide‐polysaccharide interactions 293–316 Nucleic acid‐small molecule interactions 317–348 Small molecule interactions …”

Section: Introductionmentioning

confidence: 99%

Survey of the year 2009: applications of isothermal titration calorimetry

Falconer

Collins

2010

J. Mol. Recognit.

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Isothermal titration calorimetry (ITC) is now an established and invaluable method for determining the thermodynamic constants, association constant and stoichiometry of molecular interactions in aqueous solutions. The technique has become widely used by biochemists to study protein interaction with other proteins, small molecules, metal ions, lipids, nucleic acids and carbohydrates; and nucleic acid interaction with small molecules. The drug discovery industry has utilized this approach to measure protein (or nucleic acid) interaction with drug candidates. ITC has been used to screen candidates, guide the design of potential drugs and validate the modelling used in structure-based drug design. Emerging disciplines including nanotechnology and drug delivery could benefit greatly from ITC in enhancing their understanding and control of nano-particle assembly, and drug binding and controlled release.

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Section: Introductionmentioning

confidence: 99%

Survey of the year 2009: applications of isothermal titration calorimetry

Falconer

Collins

2010

J. Mol. Recognit.

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“…The ITC data were analyzed using the software provided with the instrument, and the stoichiometry of the complex was found to be a 1:1 ratio for the sensors. 46 The binding constants were calculated to be 3 × 10 7 , 2 × 10 7 , and 3 × 10 7 M −1 , respectively, mRA, dRA, and tRA. The free energy change ΔG for the binding event is calculated as −42.1 ± 0.4 kJ mol −1 , but notable difference in other associated thermodynamic parameters ΔS and ΔH with respect to the receptors were noted, and thus, it can be concluded that the binding event is driven by the entropy and enthalpy factors.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Triarylamine Rhodanine Derivatives as Red Emissive Sensor for Discriminative Detection of Ag⁺ and Hg²⁺ ions in Buffer-Free Aqueous Solutions

Thamaraiselvi¹,

Duraipandy

Kiran

et al. 2019

ACS Sustainable Chem. Eng.

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A completely water-soluble, red emitting, multibranched sensor based on the electron-rich triphenylamine and electron-deficient rhodanine-3-acetic acid has been developed. The sensors mRA, dRA, and tRA, respectively, have one, two, and three rhodanine-3-acetic acid groups, responsible for the interaction with the metal ions as well as the solubility of the probe in water. mRA, dRA, and tRA senses Ag+ and Hg2+ ions in a buffer-free aqueous solution with the lowest detection level of 0.06 and 0.02 ppm, respectively. The yellow color of free sensor turns into purple and colorless in the presence of Ag+ and Hg2+ ions, respectively, which can be witnessed even by the naked eye. The metal ion preferentially binds with electron-deficient rhodanine-3-acetic acid owing to the presence of an ideal coordination environment. The distinctly different signals for Ag+ and Hg2+ ions occur because of the dissimilar binding modes, wherein the former extends and the latter breaks the π-electron conjugation that results in a different signaling mechanism. Nevertheless, the additional binding sites of dRA and tRA influences the binding constant and sensitivity; however, additional metal ion binding does not occur because of the changes in the electronic properties after initial binding. The applicability of these sensors in the biological medium was also tested using HaCaT cells using Ag+ and Hg2+ ions, which demonstrated the quenching of intense red fluorescence of the probe, and thus, these probes can be also be used as a potential biosensor.

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“…For background to polydentate Schiff bases in coordination chemistry, see: Souza et al (1985); Dixit et al (2009). For information on their uses as stereospecific catalysts, see: Kureshy et al (1999); Aoyama et al (1986).…”

Section: Related Literaturementioning

confidence: 99%