Synthesis of a novel glucose capped gold nanoparticle as a better theranostic candidate

Suvarna, Saritha; Das, Ujjal; Kc, Sunil; Mishra, Snehasis; Sudarshan, M.; Saha, Krishna Das; Dey, Sanjit; Chakraborty, Anindita; Narayana, Y.

doi:10.1371/journal.pone.0178202

Cited by 66 publications

(37 citation statements)

References 71 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The use of nanotechnology to produce metallic nanostructures has gained interest, especially in medicine [ 17 , 18 , 19 ]. The fascinating and insightful use of optical, chemical and catalytic properties of noble metal NPs depends on the metal source, nanoparticle sizes and shapes and surface chemistry.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Biogenic Gold Nanoparticles from Terminalia mantaly Extracts and the Evaluation of Their In Vitro Cytotoxic Effects in Cancer Cells

et al. 2020

View full text Add to dashboard Cite

Scientists have demonstrated the potential of plant materials as ‘green’ reducing and stabilizing agents for the synthesis of gold nanoparticles (AuNPs) and opened new ecofriendly horizons to develop effective and less harmful treatment strategies. The current study demonstrated the use of Terminalia mantaly (TM) extracts to synthesize AuNPs with enhanced cytotoxic effects. The TM-AuNPs were synthesized at 25 and 70 °C using water (WTM) and methanolic (MTM) extracts of the leaf, root and stem/bark parts of the plant. The TM-AuNPs were characterized using UV–visible spectrophotometry, dynamic light scattering (DLS), transmission electron microscopy, energy dispersive X-ray (EDX), selection area electron diffraction (SAED) and Fourier transform infrared (FTIR) spectroscopy. Majority of the TM-AuNPs were spherical with a mean diameter between 22.5 and 43 nm and were also crystalline in nature. The cytotoxic effects of TM-AuNPs were investigated in cancer (Caco-2, MCF-7 and HepG2) and non-cancer (KMST-6) cell lines using the MTT assay. While the plant extracts showed some cytotoxicity towards the cancer cells, some of the TM-AuNPs were even more toxic to the cells. The IC50 values (concentrations of the AuNPs that inhibited 50% cell growth) as low as 0.18 µg/mL were found for TM-AuNPs synthesized using the root extract of the plant. Moreover, some of the TM-AuNPs demonstrated selective toxicity towards specific cancer cell types. The study demonstrates the potential of TM extracts to produce AuNPs and describe the optimal conditions for AuNPs using TM extracts. The toxicity of some the TM-AuNPs can possibly be explored in the future as an antitumor treatment.

show abstract

Section: Introductionmentioning

confidence: 99%

Synthesis of Biogenic Gold Nanoparticles from Terminalia mantaly Extracts and the Evaluation of Their In Vitro Cytotoxic Effects in Cancer Cells

et al. 2020

View full text Add to dashboard Cite

show abstract

“…It has been reported that glucose-stabilized gold nanoparticles exhibit a strong surface plasmonic peak at 540 nm, for nanoparticles with diameter of 19 nm. 38 In the case of the Fe 3 O 4 @AuNPs covered with layers of Au in two steps, the surface plasmon resonance peak is shifted towards higher wavelengths, indicating that the thickness of the Au shell has increased. Moreover, the surface plasmon resonance peak is both sharper and more intense in the case of Fe 3 O 4 @AuNPs covered with Au in two steps, suggesting that the Au shell became more uniform in the latter case.…”

Section: Synthesis and Characterization Of Fe 3 O 4 @Aunpsmentioning

confidence: 97%

<p>Assessment of Gold-Coated Iron Oxide Nanoparticles as Negative T2 Contrast Agent in Small Animal MRI Studies</p>

Iancu¹,

Albu²,

Chiriac³

et al. 2020

IJN

View full text Add to dashboard Cite

Purpose: Magnetic resonance imaging (MRI) contrast agents are pharmaceuticals that enable a better visualization of internal body structures. In this study, we present the synthesis, MRI signal enhancement capabilities, in vitro as well as in vivo cytotoxicity results of gold-coated iron oxide nanoparticles (Fe 3 O 4 @AuNPs) as potential contrast agents. Methods: Fe 3 O 4 @AuNPs were obtained by synthesizing iron oxide nanoparticles and gradually coating them with gold. The obtained Fe 3 O 4 @AuNPs were characterized by spectroscopies, transmission electron microscopy (TEM) and energy dispersive X-ray diffraction. The effect of the nanoparticles on the MRI signal was tested using a 7T Bruker PharmaScan system. Cytotoxicity tests were made in vitro on Fe 3 O 4 @AuNP-treated retinal pigment epithelium cells by WST-1 tests and in vivo by following histopathological changes in rats after injection of Fe 3 O 4 @AuNPs. Results: Stable Fe 3 O 4 @AuNPs were successfully prepared following a simple and fast protocol (<1h worktime) and identified using TEM. The cytotoxicity tests on cells have shown biocompatibility of Fe 3 O 4 @AuNPs at small concentrations of Fe (<1.95×10 −8 mg/ cell). Whereas, at higher Fe concentrations (eg 7.5×10 −8 mg/cell), cell viability decreased to 80.88±5.03%, showing a mild cytotoxic effect. MRI tests on rats showed an optimal Fe 3 O 4 @AuNPs concentration of 6mg/100g body weight to obtain high-quality images. The histopathological studies revealed significant transient inflammatory responses in the time range from 2 hours to 14 days after injection and focal cellular alterations in several organs, with the lung being the most affected organ. These results were confirmed by hyperspectral microscopic imaging of the same, but unstained tissues. In most organs, the inflammatory responses and sublethal cellular damage appeared to be transitory, except for the kidneys, where the glomerular damage indicated progression towards glomerular sclerosis. Conclusion: The obtained stable, gold covered, iron oxide nanoparticles with reduced cytotoxicity, gave a negative T 2 signal in the MRI, which makes them suitable for candidates as contrast agent in small animal MRI applications.

show abstract

“…To overcome non-specic aggregation and low specicity, we explored sucrose as a capping agent. 16,20,21 Sucrose-capped AuNPs were synthesized using the two different methods (termed Type 1 and Type 2, ESI Table 1 ‡). The two methodologies yielded particles with sizes in the range of 49.23 nm (AE0.44 nm) and 90.12 nm (AE14.32) for Type 1 and Type 2 particles, respectively (ESI Fig.…”

Section: Capping Agents Inuence Particle Stability and Sensitivity Omentioning

confidence: 99%

Aptamer–gold nanoparticle conjugates for the colorimetric detection of arboviruses and vector mosquito species

et al. 2019

View full text Add to dashboard Cite

show abstract

Synthesis of a novel glucose capped gold nanoparticle as a better theranostic candidate

Cited by 66 publications

References 71 publications

Synthesis of Biogenic Gold Nanoparticles from Terminalia mantaly Extracts and the Evaluation of Their In Vitro Cytotoxic Effects in Cancer Cells

Synthesis of Biogenic Gold Nanoparticles from Terminalia mantaly Extracts and the Evaluation of Their In Vitro Cytotoxic Effects in Cancer Cells

<p>Assessment of Gold-Coated Iron Oxide Nanoparticles as Negative T2 Contrast Agent in Small Animal MRI Studies</p>

Aptamer–gold nanoparticle conjugates for the colorimetric detection of arboviruses and vector mosquito species

Contact Info

Product

Resources

About