Synthesis of a Novel Class of Azacrown Macrocycles and Lariat Crown Ethers Containing Two 1,2,4-Triazole Rings as Subunits

Abstract

S y n t h e s i s o f A z a c r o w n M a c r o c y c l e s a n d L a r i a t C r o w n E t h e r s Abstract: Azacrown macrocycles were prepared in 70-76% yield by the condensation reaction of 1,2-, 1,3-, and 1,4-bis(4-amino-5-mercapto-4H-1,2,4-triazol-3-yl)alkanes with bisaldehydes in acetic acid under reflux. Reaction of two of these azacrown macrocycles with iodomethane and benzyl chloride furnished exclusively the target lariat macrocycles in good yields.

Efficient synthesis of Some Novel Symmetrical and Unsymmetrical Pyridine bis-1,2,4-triazoles and bis-1,3,4-thiadiazoles

“…17 Moreover, it has been indicated in several reports that bisheterocyclic compounds displayed much better antibacterial activity than mono-heterocyclic compounds. [18][19][20][21] In view of these observations, and also in continuation of our previous work on the synthesis of bis-heterocyclic compounds, [22][23][24][25] we now report the synthesis of some novel pyridine bis-1,2,4-triazoles and bis-1,3,4-thiadiazoles.…”

Synthesis of some pyridyl and cyclohexyl substituted 1,2,4 triazole, 1,3,4-thiadiazole and 1,3,4-oxadiazole derivatives

“…Prompted by these observations and as a continuation of our research program on the synthesis of 1,2,4-triazole derivatives [17][18][19][20][21], herein we wish to disclose synthesis of some novel five memberd heterocycle derivatives via intramolecular cyclization reactions in good yield.…”

Regioselective Synthesis of New Bibracchial Lariat Ethers

“…In continuation of our interst to develop the synthesis of new azathiacrown macrocycles and lariat ether [3,18], we report herein, a simple and efficient method for the regioselective synthesis of novel BiBLES 4a-e. In this article, we demonstrate a novel method to introduce 1,2,4-triazolo [3,4-b] [1,3,4]thiadiazines rings into macrocycles.…”