Synthesis of a new reactivator of tabun-inhibited acetylcholinesterase

Microwave-assisted Quaternization of Various Pyridine Derivatives and their Antibacterial Activity

“…It was performed quaternization reaction of isonicotinamide with 1, 4-dibromobutane in acetonitrile and after 18 hours at 65 to 70 °C the product in 96 % yield was obtained. [27] Pyridine-2-aldoxime methyl iodide (2-PAM) is the most common nerve agent. According to Poziomiek et al, 2-PAM was synthesized for the first time in ethanol.…”

Synthesis of monooxime-monocarbamoyl bispyridinium compounds bearing (E)-but-2-ene linker and evaluation of their reactivation activity against tabun- and paraoxon-inhibited acetylcholinesterase

“…The position of oxime determines which type of OPC will be better accessible for reactivation [18 -19,33 -34]. In the event of GA, the hydroxyiminomethyl (oxime) in position-four is preferred (1 -2, 5, 8, 11) [20][21][22]. For paraoxoninhibited AChE, position-four of the oxime group (2, 11) also gave better reactivation ability although the differences are not so remarkable (5 in contrast to 6) [25].…”

“…Several potent substances against GA-inhibited AChE were investigated recently in our group -K048 (1) and K075 (2) (Figure 3) [20][21][22]. In order to combine these two molecules, new potential reactivators were designed.…”

“…The only previously known oxime BI-6 (6) was prepared by a novel approach and, moreover, NMR and MS analysis were determined, since the foregoing literature data were not available [26]. The synthesized compounds were tested in vitro on tabun (GA)-and paraoxon-inhibited AChE and compared to known oximes (pralidoxime, obidoxime, HI-6) and promising oximes against GA (K048, K075) [20][21][22].…”

Group Contribution Methods for Estimation of Selected Physico-Chemical Properties of Organic Compounds

“…In comparison with previous cases (estimations of thermophysical properties) authors have only less experimental data for development of model (about 20 for each of cases). Due to their long names and complex chemical structures these compounds in this chapter only are presented as their codes taken from original papers (Kuča & Kassa, 2003;Kuča et al, 2003a;Kuča et al, 2003b;Kuča et al, 2003c;Kuča & Patočka, 2004;Kuča & Cabal, 2004a;Kuča & Cabal, 2004b;Kuča et. al., 2006.…”