Synthesis of a New NIR Fluorescent Nd Complex Labeling Agent

Aita, Kazuki; Temma, Takashi; Shimizu, Yoichi; Kuge, Yuji; Seki, Koh‐ichi; Saji, Hideo

doi:10.1007/s10895-009-0542-3

Cited by 7 publications

(5 citation statements)

References 32 publications

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“…Aita et al discussed the use of an NIR fluorescent Ni complex containing a fluorescein and a crown ether moiety. 203 This low molecular weight complex can be excited at 488 nm with a fluorescence band in the 880À900 nm region. Avidin moiety was added to the Ni complex for bioconjugation purposes.…”

Section: ' Near-infrared Fluorescencementioning

confidence: 99%

“…A significant number of research articles were published about NIR fluorescence applications during the last two years. Aita et al discussed the use of an NIR fluorescent Ni complex containing a fluorescein and a crown ether moiety . This low molecular weight complex can be excited at 488 nm with a fluorescence band in the 880–900 nm region.…”

Section: Near-infrared Fluorescencementioning

confidence: 99%

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Molecular Fluorescence, Phosphorescence, and Chemiluminescence Spectrometry

et al. 2011

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Analytical Chemistry REVIEW citations were found through individual searches by the various authors who wrote a particular section of this Review. In an effort to more effectively accomplish this goal, we have included authors who are knowledgeable in the various subtopics of this Review.Coverage is limited to articles that describe new developments in the theory and practice of molecular luminescence for chemical analysis in the ultraviolet, visible, and near-infrared region. We have included two new sections in this Review on fluorescence nanoparticles and green chemistry. Discussions of cited work are intended to be more critical and focused than in previous reviews. In general, citations are limited to journal articles and do not include patents, proceedings, reports, and dissertations. In an effort to reduce the length of this Review we have attempted to limit duplicate citations between sections by retaining the same reference number for a given citation which is cited under more than one heading.As in previous years, we are not able to provide extensive coverage of all developments of relevance to the extremely broad field of molecular fluorescence, phosphorescence, and chemiluminescence. Instead, we have focused on important advances of general interest and relevance to the field of analytical chemistry, rather than extensions of previous advances. In addition, we have attempted to balance inclusion of a sufficient number of highly relevant, high-impact references to adequately survey the field with ample descriptions of individual citations for better clarification. If you feel that we have omitted an important article published during the above referenced time period, please forward the reference to one of us and we will be certain to consider it for the next review.

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Section: ' Near-infrared Fluorescencementioning

confidence: 99%

Section: Near-infrared Fluorescencementioning

confidence: 99%

Molecular Fluorescence, Phosphorescence, and Chemiluminescence Spectrometry

et al. 2011

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“…(18) Mouse immunoglobulin G 3 , kappa mAb (ab18392; Abcam, Cambridge, UK) was labeled with ROX in a similar way to obtain a negative control (NC Ab-ROX).…”

Section: Methodsmentioning

confidence: 99%

Development of membrane type‐1 matrix metalloproteinase‐specific activatable fluorescent probe for malignant tumor detection

et al. 2011

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Membrane type-1 matrix metalloproteinase (MT1-MMP) is a protease that activates pro-MMP-2 and pro-MMP13, which are related to tumor malignancy. Therefore, probes that specifically image MT1-MMP would be useful for malignant tumor diagnosis. In the present study, we prepared rhodamine X-conjugated anti-MT1-MMP antibody (anti-MT1-MMP mAb-ROX) as an activatable fluorescent probe and evaluated its usefulness for MT1-MMP-specific imaging. Anti-MT1-MMP mAb-ROX was obtained in a quenched form with approximately three ROX molecules per mAb. Its fluorescence intensity increased approximately 14-fold in the presence of detergent, which is suitable for activatable systems. C6 glioma cells and MCF-7 human breast adenocarcinoma cells were used as MT1-MMP-positive and MT1-MMP-negative models, respectively. The fluorescence intensity of C6 cells treated with anti-MT1-MMP mAb-ROX, but not ROX-conjugated isotype control antibody (NC Ab-ROX), increased with time and was significantly higher than that of MCF-7 cells at 6 h (P < 0.001). The fluorescence intensity of cells treated with anti-MT1-MMP mAb-ROX was also suppressed by pre-treatment with a MT1-MMP endocytosis inhibitor (P < 0.05). Furthermore, the probes were intravenously administered to C6 and MCF-7 xenografted mice. The tumor-to-muscle (T ⁄ M) ratio of the anti-MT1-MMP mAb-ROX group was 15.1 ± 3.2 at 48 h and was significantly higher than that of the NC Ab-ROX group (T ⁄ M ratio = 4.6 ± 3.0, P < 0.05) in C6 xenografted mice, while the T ⁄ M ratio of the anti-MT1-MMP mAb-ROX and NC Ab-ROX groups was not different in MCF-7 xenografted mice. These findings suggest that anti-MT1-MMP mAb-ROX is a promising probe for specifically detecting MT1-MMP-expressing tumors.

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“…Complexes of rare earth elements (lanthanides) containing Nd 3+ , Er 3+ , Yb 3+ and Tm 3+ in the near-infrared region have been widely developed in recent years [62,63,64,65]. Compared to NIFPs such as organic dyes and semiconductor nanocrystals, Near-infrared fluorescent rare earth complexes have unique advantages such as large Stokes’ displacement, long fluorescence lifetime and no photobleaching [66].…”

Section: Near-infrared Fluorescent Probe Typesmentioning

confidence: 99%

Research Progress of Near-Infrared Fluorescence Immunoassay

Xiaohui

Zhang

et al. 2019

Micromachines

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Near-infrared fluorescence probes (NIFPs) have been widely used in immunoassay, bio-imaging and medical diagnosis. We review the basic principles of near-infrared fluorescence and near-infrared detection technology, and summarize structures, properties and characteristics of NIFPs (i.e., cyanines, xanthenes fluorescent dyes, phthalocyanines, porphyrin derivates, single-walled carbon nanotubes (SWCNTs), quantum dots and rare earth compounds). We next analyze applications of NIFPs in immunoassays, and prospect the application potential of lateral flow assay (LFA) in rapid detection of pathogens. At present, our team intends to establish a new platform that has highly sensitive NIFPs combined with portable and simple immunochromatographic test strips (ICTSs) for rapid detection of food-borne viruses. This will provide technical support for rapid detection on the port.

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Synthesis of a New NIR Fluorescent Nd Complex Labeling Agent

Cited by 7 publications

References 32 publications

Molecular Fluorescence, Phosphorescence, and Chemiluminescence Spectrometry

Molecular Fluorescence, Phosphorescence, and Chemiluminescence Spectrometry

Development of membrane type‐1 matrix metalloproteinase‐specific activatable fluorescent probe for malignant tumor detection

Research Progress of Near-Infrared Fluorescence Immunoassay

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