“…The reaction proceeded via the common intermediate A, which was readily accessed by the reaction of 1-aroyl-2-styryl sulfonylethenes 20 and hydrazine hydrate (Scheme 12). 30 Ketene dithioacetals are important intermediates in organic synthesis. 24 Liu and coworkers expanded the synthesis of polysubstituted fused bicyclic pyrrole systems 25 via the domino reaction of 1,5-dielectrophilic substrates such as a-alkenoyl ketene dithioacetals 23 with a-acidic isocyanides 1a using mild conditions in 18-90% yield (Scheme 13).…”
p-Tosylmethyl isocyanide (TosMIC), an α-acidic isocyanide has emerged as a privileged reagent to access biologically relevant fused heterocycles and some natural products like (−)-ushikulide A, variolin B, porphobilinogen and mansouramycin B.
“…The reaction proceeded via the common intermediate A, which was readily accessed by the reaction of 1-aroyl-2-styryl sulfonylethenes 20 and hydrazine hydrate (Scheme 12). 30 Ketene dithioacetals are important intermediates in organic synthesis. 24 Liu and coworkers expanded the synthesis of polysubstituted fused bicyclic pyrrole systems 25 via the domino reaction of 1,5-dielectrophilic substrates such as a-alkenoyl ketene dithioacetals 23 with a-acidic isocyanides 1a using mild conditions in 18-90% yield (Scheme 13).…”
p-Tosylmethyl isocyanide (TosMIC), an α-acidic isocyanide has emerged as a privileged reagent to access biologically relevant fused heterocycles and some natural products like (−)-ushikulide A, variolin B, porphobilinogen and mansouramycin B.
Synthesis of a New Class of Sulfones Linked Bisheterocycles. -(PADMAVATHI*, V.; REVATHI, N.; RAJASEKHAR, C.; PREMAKUMARI, C.; J. Heterocycl. Chem. 50 (2013) 3, 579-584, http://dx.
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