Synthesis of a Chiral Precursor for No-Carrier-Added (NCA) PET Tracer 6-[18F]Fluoro-L-dopa Based on Regio- and Enantioselective Alkylation of 2,4-Bis(chloromethyl)-5-iodoanisole

Abstract

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Three-Step, “One-Pot” Radiosynthesis of 6-Fluoro-3,4-Dihydroxy-l-Phenylalanine by Isotopic Exchange

“…Kuroda et al (17) described the synthesis of a similar precursor with this strategy by choosing a homochiral imidazolidinone derivative (according to Seebach et al (18)) as the masked amino acid functionality and iodide as the leaving group in the formyl-activated 18 F exchange reaction. Unfortunately, no 18 F-labeling results with this precursor have been reported so far.…”