Synthesis of a chiral ionic liquid, cholinium-clindamycin phosphate, as sole chiral selector in capillary electrophoresis

Xu, Hui; Du, Yingxiang; Feng, Zijie; Sun, Xiaodong; Liu, Jie

doi:10.1016/j.chroma.2019.460721

Cited by 22 publications

(8 citation statements)

References 41 publications

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“…Both the calculated free binding energies and the identified enantiomer-CS interactions indicated greater enantiomer affinities and enantioselectivity in the case of the IL CS in comparison to clindamycin. The computing results were in accordance with the experimental results [ 72 ].…”

Section: Antibiotics As Css In Cesupporting

confidence: 85%

The Use of Antibiotics as Chiral Selectors in Capillary Electrophoresis: A Review

Hancu¹,

Papp²,

Szekely-Szentmiklosi³

et al. 2022

Molecules

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Chirality is becoming an essential issue in modern pharmaceutical research as regulatory agencies emphasize the safety and efficiency of enantiomers in drug development. The development of efficient and reliable chiral separation methods became a necessity in the last 30 years, and capillary electrophoresis (CE), due to its relatively low costs and “green” features, is attracting increased attention. Cyclodextrin (CD) and their derivatives are the most frequently used chiral selectors (CSs) in CE, however, the use of antibiotics as CSs represents an interesting alternative. Various classes of antibiotics (aminoglycosides, ansamycins, glycopeptides, lincosamides, macrolides, tetracyclines) have been used more or less successfully for the enantio-separation of pharmaceuticals. Antibiotics offer the possibility of a multitude of potential interactions (electrostatic, inclusion, hydrogen bonding, etc.) due to their chemical diversity, allowing the enantio-separation of analytes with a wide range of structural characteristics. This article aims to review the application of various classes of antibiotics in the CE enantio-separation of pharmaceuticals. Antibiotic physiochemical characteristics, variables impacting enantio-separation, advantages, and disadvantages when certain antibiotics are used as CSs in CE are also explored.

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Section: Antibiotics As Css In Cesupporting

confidence: 85%

The Use of Antibiotics as Chiral Selectors in Capillary Electrophoresis: A Review

Hancu¹,

Papp²,

Szekely-Szentmiklosi³

et al. 2022

Molecules

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“…The enantiomer migration order could be correlated to the formation of hydrogen bonds established between the analyte enantiomers and the CILs in molecular modeling studies. Similar data were obtained for the CILs derived from maltobionic acid [93] and clindamycin phosphate [94].…”

Section: Structures Of Selector-selectand Complexessupporting

confidence: 81%

Advances of capillary electrophoresis enantioseparations in pharmaceutical analysis (2017–2020)

2021

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Capillary electrophoresis is a powerful technique for the analysis of polar chiral compounds and has been widely accepted for analytical enantioseparations of drug compounds in pharmaceuticals and biological media. In addition, many mechanistic studies have been conducted in an attempt to rationalize enantioseparations in combination with spectroscopic and computational techniques. The present review will focus on recent examples of mechanistic aspects and summarize recent applications of stereoselective pharmaceutical and biomedical analysis published between January 2017 and November 2020. Various separation modes including electrokinetic chromatography in combination with several detection modes including laser-induced fluorescence, mass spectrometry and contactless conductivity detection will be discussed. A general trend also observed in other analytical techniques is the application of quality by design principles in method development and optimization.

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“…New chiral ILs have been developed in the past 2 years. For instance, a chiral IL, cholinium-clindamycin phosphate (Ch-CP), was developed and able to improve the separation of five racemic drugs, compared to clindamycin phosphate (CP) [41]. Noticeably, ILs can be mixed with other chiral selectors to produce a synergistic system for separation improvement.…”

Section: Ionic Liquid As Buffer Additivesmentioning

confidence: 99%

Recent (2018–2020) development in capillary electrophoresis

Gao

Zhong

2021

Anal Bioanal Chem

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Development of new capillary electrophoresis (CE) methodology and instrumentation, as well as application of CE to solve new problems, remains an active research area because of the attractive features of CE compared to other separation techniques. In this review, we focus on the representative works about sample preconcentration, separation media or capillary coating development, detector construction, and multidimensional separation in CE, which are judiciously selected from the papers published in 2018-2020.

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Synthesis of a chiral ionic liquid, cholinium-clindamycin phosphate, as sole chiral selector in capillary electrophoresis

Cited by 22 publications

References 41 publications

The Use of Antibiotics as Chiral Selectors in Capillary Electrophoresis: A Review

The Use of Antibiotics as Chiral Selectors in Capillary Electrophoresis: A Review

Advances of capillary electrophoresis enantioseparations in pharmaceutical analysis (2017–2020)

Recent (2018–2020) development in capillary electrophoresis

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