Abstract:Aspochalasins
are leucine-derived cytochalasins. Their complexity is often associated to a
high degree of biosynthetic oxidative transformations that could inspire a
two-phase strategy in total synthesis. In that context, we describe the
synthesis of a putative biomimetic tetracyclic intermediate. The key
constructive steps are an intramolecular Diels-Alder reaction to install the
characteristic isoindolone core of cytochalasins, whose branched precursor was
obtained from a stereoselective Ireland-Claisen rear… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.