Synthesis of 7‐Phenylindole Derivatives through Rhodium‐Catalyzed Dehydrogenative Coupling of 2‐(Acetylamino)‐1,1’‐biphenyls with Alkynes

Abstract

The dehydrogenative coupling of 2-(acetylamino)-1,1'-biphenyls with internal alkynes proceeds regioselectively under rhodium catalysis to afford the corresponding 7-phenylindole derivatives. Combining with Suzuki-Miyaura coupling, the processes provide easy access to the 7-phenylindole structures from readily available starting materials.