Synthesis of 5-substituted 3-(2-oxopropyl)tetrahydrofuran-2-ones and heterocyclic compounds on their base

Kochikyan, T. V.; Arutyunyan, E. V.; Arutyunyan, V. S.; Avetisyan, A. A.

doi:10.1134/s1070428008120130

Cited by 7 publications

(1 citation statement)

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“…2, а-l and 3, a-k were published in articles [16,17], however further biological studies of the newly synthesized compounds were carried out later. The results obtained are quite interesting and once again confirm that the research in the field of γ-lactones is very valuable and the likelihood of their application in practice is high.…”

Section: Introductionmentioning

confidence: 99%

Study of the Biological Properties of Semi- And Thiosemicarbazones of Carbonyl Derivatives of 4-Butanolides

Ghochikyan¹,

Galstyan²,

Stepanyan

et al. 2021

Proc. YSU B: Chem. Biol. Sci.

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Based on carbonyl derivatives of 4-substituted-4-butanolides, the appropriate semi- and thiosemicarbazones have been synthesized. It has been found that some representatives of thiosemicarbazones have pronounced algicidal activity against filamentous green alga Cladophora and blue-green alga (cyanobacterium) Synechocystis and some of the semi- and thiosemicarbazones exhibit moderate antitumor activity. The assessment of the antitumor activity of the compounds was carried out using strains of syngeneic and allogeneic tumor systems as test-objects: lymphocytic leukemia P-388, Lewis lung carcinoma, B16 melanoma and Ehrlich’s ascites tumor. It has also been established that some representatives of thiosemicarbazones exhibit antimutagenic properties. It has been reliably proven that with the formation of a thiazole ring, all properties disappear and a new property in the series of thiazololactones is revealed – antibacterial․

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Section: Introductionmentioning

confidence: 99%