Synthesis of 5‐Substituted 2‐Methylbenzimidazoles with Anticancer Activity.

El-Naem, Sh. I.; El-Nzhawy, A. O.; Diwani, Hoda I. El; Hamid, Abid

doi:10.1002/chin.200328139

Cited by 2 publications

(3 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[173][174][175] Various benzimidazole substituted derivatives 33-35 are reported as cytotoxic against lung and breast cancers. 176,177 Abdel-Mohsen et al developed benzimidazoles conjugated with pyrimidine and explored their anticancer activities for twelve carcinoma cell lines (KB, SK OV-3, SF-268, NCI H460, RKOP27 HL60 U937 K562 G361 SK-MEL-28 GOTO NB-1). 178 Compound 36 emerged as the most active against non-small lung cancer (NCI H460), ovarial carcinoma (SK OV-3) and leukemia (HL60) but was still less active than the standards.…”

Section: Miscellaneous Biological Targets Of Imidazolesmentioning

confidence: 99%

“…179 Compounds 41 and 42 possess significant inhibitory activity against Burkitt's lymphoma promotion, 177 and 43, 44 (log GI 50 = −5.61) and 45 have high cytotoxic activity against non-small lung cancer and breast cancer, 43 (log GI 50 = 5.77) and 44 (log GI 50 = 5.36). 176,178 Development of benzimidazoles is a continuous goal of researchers, and its pyrazoline 46 analogues 180 and thiazole 47 derivatives 181 have been developed as potent anticancer agents for various cancer cell lines. Furthermore, another series of benzimidazoles as anti-tumour agents have been reported by Refaat, 182 and some imidazoles, 4-amino-thioxothiazole 48, 4-oxothiazolidine 49, 4-fluorobenzylidene 50, and cycloalkylidene were found to be potent anti-tumour agents.…”

Section: Miscellaneous Biological Targets Of Imidazolesmentioning

confidence: 99%

See 1 more Smart Citation

Imidazoles as potential anticancer agents

2017

View full text Add to dashboard Cite

Cancer is a black spot on the face of humanity in this era of science and technology. Presently, several classes of anticancer drugs are available in the market, but issues such as toxicity, low efficacy and solubility have decreased the overall therapeutic indices. Thus, the search for new promising anticancer agents continues, and the battle against cancer is far from over. Imidazole is an aromatic diazole and alkaloid with anticancer properties. There is considerable interest among scientists in developing imidazoles as safe alternatives to anticancer chemotherapy. The present article describes the structural, chemical, and biological features of imidazoles. Several classes of imidazoles as anticancer agents based on their mode of action have been critically discussed. A careful observation has been made into pharmacologically active imidazoles with better or equal therapeutic effects compared to well-known imidazole-based anticancer drugs, which are available on the market. A brief discussion of the toxicities of imidazoles has been made. Finally, the current challenges and future perspectives of imidazole based anticancer drug development are conferred.

show abstract

Section: Miscellaneous Biological Targets Of Imidazolesmentioning

confidence: 99%

Section: Miscellaneous Biological Targets Of Imidazolesmentioning

confidence: 99%

Imidazoles as potential anticancer agents

2017

View full text Add to dashboard Cite

show abstract

“…Compounds 96 and 97 possessed significant inhibitory activities against Burkitt's lymphoma promotion . Compounds 98 , 99 (log GI 50 = 5.61), and 100 had high cytotoxic activities against non‐small lung cancer while their result on breast cancer were 98 (log GI 50 = 5.77) and 99 (log GI 50 = 5.36) . Other benzimidazole templates with strong in vitro antitumor activities against various cancer cell lines include 101 – 105 (Fig.…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

Functionalized Benzimidazole Scaffolds: Privileged Heterocycle for Drug Design in Therapeutic Medicine

Ajani

Aderohunmu

Ikpo

et al. 2016

Archiv der Pharmazie

View full text Add to dashboard Cite

Benzimidazole derivatives are crucial structural scaffolds found in diverse libraries of biologically active compounds which are therapeutically useful agents in drug discovery and medicinal research. They are structural isosteres of naturally occurring nucleotides, which allows them to interact with the biopolymers of living systems. Hence, there is a need to couple the latest information with the earlier documentations to understand the current status of the benzimidazole nucleus in medicinal chemistry research. This present work unveils the benzimidazole core as a multifunctional nucleus that serves as a resourceful tool of information for synthetic modifications of old existing candidates in order to tackle drug resistance bottlenecks in therapeutic medicine. This manuscript deals with the recent advances in the synthesis of benzimidazole derivatives, the widespread biological activities as well as pharmacokinetic reports. These present them as a toolbox for fighting infectious diseases and also make them excellent candidates for future drug design.

show abstract

Synthesis of 5‐Substituted 2‐Methylbenzimidazoles with Anticancer Activity.

Cited by 2 publications

References 1 publication

Imidazoles as potential anticancer agents

Imidazoles as potential anticancer agents

Functionalized Benzimidazole Scaffolds: Privileged Heterocycle for Drug Design in Therapeutic Medicine

Contact Info

Product

Resources

About