Synthesis of 5<i>H</i>-chromeno[3,4-<i>c</i>]pyridine derivatives through ruthenium-catalyzed [2 + 2 + 2] cycloaddition

Parisot, William; Huvelle, Steve; Haddad, Mansour; Lefèvre, Guillaume; Phansavath, Phannarath; Ratovelomanana‐Vidal, Virginie

doi:10.1039/d2qo01918c

Org. Chem. Front.

2023

DOI: 10.1039/d2qo01918c

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Synthesis of 5H-chromeno[3,4-c]pyridine derivatives through ruthenium-catalyzed [2 + 2 + 2] cycloaddition

William Parisot

Steve Huvelle

Mansour Haddad

et al.

Abstract: Efficient access to 5H-chromeno[3,4-c]pyridines using Ru-catalyzed [2 + 2 + 2] cycloaddition of α,ω-diynes with cyanamides was developed, providing valuable tricyclic pyridine building blocks and enabling access to a biologically relevant intermediate.

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Synthetic Methods for Various Chromeno-fused Heterocycles and their Potential as Antimicrobial Agents

Agrawal,

Goswami,

Pathak

2024

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Chromenes are a significant family of heterocyclic chemicals that have a wide range of biological applications, a simple chemical structure, and only mildly undesirable side effects. The synthesis of a wide range of chromene analogs that displayed unexpected behaviors via numerous mechanisms was investigated by a number of different research teams, which led to the discovery of multiple pathways for their synthesis. In addition, different chromene-fused heterocycles exhibit a wide variety of fascinating biological actions, including those that are anticancer, anticonvulsant, antibacterial, anticholinesterase, antituberculosis, and anti-diabetic. In light of this, the purpose of this study is to highlight the many synthesis techniques and antibacterial activity associated with chromene-fused heterocyclic compounds. Moreover, such research can open avenues for exploring other therapeutic applications of these compounds in various disease areas, as their biological activities extend beyond antibacterial effects.

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Synthetic Methods for Various Chromeno-fused Heterocycles and their Potential as Antimicrobial Agents

Agrawal,

Goswami,

Pathak

2024

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show abstract

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Synthesis of 5H-chromeno[3,4-c]pyridine derivatives through ruthenium-catalyzed [2 + 2 + 2] cycloaddition

Abstract: Efficient access to 5H-chromeno[3,4-c]pyridines using Ru-catalyzed [2 + 2 + 2] cycloaddition of α,ω-diynes with cyanamides was developed, providing valuable tricyclic pyridine building blocks and enabling access to a biologically relevant intermediate.

Cited by 1 publication

References 58 publications

Synthetic Methods for Various Chromeno-fused Heterocycles and their Potential as Antimicrobial Agents

Synthetic Methods for Various Chromeno-fused Heterocycles and their Potential as Antimicrobial Agents

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