Synthesis of 5-(2-,3- and 4-methoxyphenyl)-4H-1,2,4-triazole-3-thiol derivatives exhibiting anti-inflammatory activity

Synthesis and Anticonvulsant Activity of 1-Substituted-7-Benzyloxy-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinoline

“…The derivatives of triazole exhibit a variety of activities such as antitumor, 4) antiinflammatory, 5) antimicrobial, 6,7) antifugal, 8) antithrombotic, 9) antiplatelet, 10) antiviral, 11) and anticonvulsant activities. [12][13][14] In our search for new compounds with anticonvulsant activity, 6-benzyloxy-3,4-dihydro-1H-quinoline-2-one was found although its activity is low.…”

Crystal structure of 1H-1,2,4-triazole-3-mercaptoacetic acid, C4H5N3O2S

“…Then the crude product was recrystal-lized from water and the target crystals were subjected to X-ray diffraction analysis. Discussion 1,2,4-Triazole derivatives have been extensively investigated because they possess awide spectrum of chemotherapeutic activities including anti-inflammatory [1,2], anticancer [3], antimicrobial [4][5][6], and antifungal [7]. In fact, some of their derivatives are active constituents of currently used drugs [6].…”

The chemistry of mercapto- and thione- substituted 1,2,4-triazoles and their utility in heterocyclic synthesis

“…The reaction of carboxylic acid chlorides 1 and thiosemicarbazide gave 2, which without purification were cyclized in alkaline media to yield the corresponding 2,4-dihydro-3H--1,2,4-triazole-3-thiones 3 [23][24][25][26][27][28][29][30][31][32][33][34][35][36][37] …”