Synthesis of 4H-1,4-Benzothiazine Derivatives through Condensation of o-Aminothiophenol with a-Cyano-a-methylthioacetophenones

Kano, Shinzo; Yuasa, Yoko; Ono, Toshihiro; Shibuya, Shiroshi

doi:10.3987/r-1979-05-0681

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Cited by 5 publications

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“…Thus, the reaction is regioselective and occurs through the predominately keto form of b-ketoester (Scheme 2). Although different methods have been reported in the literature [35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50], the present method has been considered as one of the best methods as far as its operational simplicity and the yields of the products are concerned.…”

Section: Resultsmentioning

confidence: 99%

Synthesis and antimicrobial activity of structurally flexible heterocycles with the 1,4-thiazine heterosystem

et al. 2011

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In this work, 4H-1,4-benzothiazines were synthesized by an efficient synthetic method in a single step involving heterocyclization of substituted 2-aminobenzenethiols with b-ketoester. The structures of the synthesized compounds were confirmed by their analytical and spectral data. The synthesized compounds were evaluated for their antimicrobial activity against bacterial species; E. coli and Bacillus cereus. The synthesized compounds showed significant activity against microorganisms, which can be correlated with the privileged heterocyclic structural scaffolds.

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