Synthesis of 4-substituted 1-methyl-5-aryl- and 1,5-diaryltetrahydropyrrole-2,3-diones and their antiviral action

Synthesis and biological activity of 5-aryl-4-acyl-3-hydroxy-1-morpholinoalkyl-3-pyrrolin-2-ones

“…Previously, we demonstrated that substituted 3-hydroxy-3-pyrrolin-2-ones possess pharmacological activity of various types, including antimicrobial [1 -3], antiinflammatory [4], analgesic [4,5], antiviral [6], and nootropic [3,5] in combination with relatively low toxicity. According to the published data, both the type and magnitude of activity depend on the character of the substituent in position 1 of the heterocycle [3,4].…”

Reaction of acylpyruvate esters with a mixture of aromatic aldehyde and 1,3-diaminopropane and pharmacological activity of the products

“…It is known that substituted 3-hydroxy-3-pyrrolin-2-ones possess various types of pharmacological activity such as anti-inflammatory [2], analgesic [3], antiviral [4], and nootropic [3]. In continuation of the search for biologically active compounds among substituted 1-aminoalkyl-3-hydroxy-3-pyrrolin-2-ones, it seemed interesting to study the reaction of methyl acylpyruvates with a mixture of aromatic aldehyde and 1,3-diaminopropane and to investigate the pharmacological activity of the products.…”

Synthesis and biological activity of 5-aryl-4-acyl-3-hydroxy-1-[2-(diethylamino)ethyl]-3-pyrrolin-2-ones

“…Taking into account that, depending on the structure of substituents in position 1 of the heterocycle, the resulting 3-hydroxy-3-pyrrolin-2-ones also exhibit antiinflammatory [2], analgesic [3], antiviral [4], and nootropic [5] effects, it was of intrest to continue the search for biologically active compounds in the series of 4,5-disubstituted 1-[(dialkylamino)alkyl]-3-hydroxy-3-pyrrolin-2-ones.…”