Synthesis of [4,6‐¹³C]nicotinic acid

Abstract

SUMMARYA simple, economic synthesis of C4,6-13C]nicotinic acid is described.

Design and synthesis of novel substituted naphthyridines as potential c-Met kinase inhibitors based on MK-2461

“…In the Skraup reaction to prepare 1,5-naphthyridine 4, m-NO 2 PhSO 3 Na was used as an oxidant, 12 which displayed a higher yield (45%) and a better reproducibility than I 2 . 13 After bromination and oxidation, 14 compound 6 was obtained in a relatively low yield of 37% for 2 steps, which was attributed to the low regioselectivities of these reactions. Then compound 7 was obtained in 62% yield by the reaction of 6 with TsCl under the condition of K 2 CO 3 .…”