Synthesis of 4‐(1‐Oxo‐isoindoline)‐, 4‐(5,6‐Dimethoxy‐1‐oxo‐isoindoline) and 4‐Acetamido‐Substituted Phenoxy‐3‐amino‐propane Derivatives and Their β₁‐, β₂‐Adrenergic Receptor Binding Studies.

Abstract

4-(5,6-Dimethoxy-1-oxo-isoindoline) and 4-Acetamido-Substituted Phenoxy-3-amino-propane Derivatives andTheir β 1 -, β 2 -Adrenergic Receptor Binding Studies. -The β-adrenoceptor binding affinity and selectivity of the synthesized compounds (V) are tested. All the tested compounds (V) exhibit better cardioselectivity than the standard cardioselective β-blocker atenolol. -(JINDAL, D. P.; SINGH, B.; SHARMA, N.; COUMAR*, M. S.; BRUNI, G.; MASSARELLI, P.; Indian J.

Recent Advances and Future Prospects of Phthalimide Derivatives

“…Phthalimide and N-substituted phthalimides are an important class of compounds because they possess important biological activities the identifiable structural features for their activity are as: hydrophobic aryl ring, a hydrogen bonding domain, an electron-donor group, another distal hydrophobic site Bhat and Al-Omar (2011). 4-(phthalimide)-substituted phenoxy propanolamines also possessed cardioselective β-adrenergic receptor binding affinity (Jindal et al, 2005). Some marketed pharmaceutical products of phthalimide derivatives are reported in table 1.…”