Synthesis of 3-(Organyloxymethyl)oxazolidines

Фарзалиев, В. М.; Abbasova, M. T.; Soltanova, Z. K.; Safarova, L. R.

doi:10.1134/s1070428022060069

Cited by 2 publications

(1 citation statement)

References 3 publications

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“…The presence in the molecules of these compounds of the N−C−O, N−C−N group, which is a structural fragment of many natural and synthetic physiologically active substances, arouses interest in them as potential biologically active compounds. Chemists are interest in alkoxymethyl derivatives of 1,3‐diheterocycloalkanes, [2–4] studied their antimicrobial activity against microorganisms [5] . At a concentration of 0.15 % alkoxymethyl derivatives of 1,3‐oxazacycloalkanes provide complete protection for cutting fluids used in the metalworking industry and extend their service life by more than 4 times [5] .…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Inhibitor Effect Novel Alkoxymethyl Derivatives of Dihetero Cycloalkanes on Carbonic Anhydrase and Acetylcholinesterase

Farzaliyev,

Ertürk,

Abbasova

et al. 2024

Chemistry & Biodiversity

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1,3‐Diheterocycloalkanes derivatives are important starting materials in fine organic synthesis. These compounds can be widely used in various fields such as industry, medicine, biotechnology and chemical technology. The paper is focused on synthesis and study of alkoxymethyl derivatives of diheterocycloalkanes (M1‐M15) and inhibition effect on carbonic anhydrase and acetylcholinesterase. The structures of compounds were confirmed by 1H and 13C NMR spectroscopy. Also, in this study alkoxymethyl derivatives of diheterocycloalkanes were assessed for their influence on various metabolic enzymes, including acetylcholinesterase (AChE) and human carbonic anhydrase isoenzymes (hCA I and hCA II). The results demonstrated that all these compounds exhibited potent inhibitory effects on all the target enzymes, surpassing the standard inhibitors, as evidenced by their IC50 and Ki values. The Ki values for the compounds concerning AChE, hCA I, and hCA II enzymes were in the ranges of 1.02±0.17‐8.38±1.02, 15.30±3.15‐ 58.14±5.17 and 24.05±3.70–312.94±27.24 nM, respectively.

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Section: Introductionmentioning

confidence: 99%

Synthesis and Inhibitor Effect Novel Alkoxymethyl Derivatives of Dihetero Cycloalkanes on Carbonic Anhydrase and Acetylcholinesterase

Farzaliyev,

Ertürk,

Abbasova

et al. 2024

Chemistry & Biodiversity

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Synthesis of Oxazolidines and Dihydroxazines via Cyclization of α-Aminated Ketones

2023

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A new approach to oxazolidines and dihydroxazines was developed by regioselective cyclization of α-aminated ketones under transition metal-free conditions. Oxazolidine derivatives were generated in the presence of chloro benziodoxole and TFA, while dihydroxazines were formed without a hypervalent iodine reagent. The reaction was performed under room temperature and gave the products in good to excellent yields.

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Synthesis of 3-(Organyloxymethyl)oxazolidines

Cited by 2 publications

References 3 publications

Synthesis and Inhibitor Effect Novel Alkoxymethyl Derivatives of Dihetero Cycloalkanes on Carbonic Anhydrase and Acetylcholinesterase

Synthesis and Inhibitor Effect Novel Alkoxymethyl Derivatives of Dihetero Cycloalkanes on Carbonic Anhydrase and Acetylcholinesterase

Synthesis of Oxazolidines and Dihydroxazines via Cyclization of α-Aminated Ketones

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