Synthesis of 3-methylflavones and their antioxidant and antibacterial activities

Abstract

An attempt was made to synthesise newer 3-methylflavones with various substitution on the ring A and B of 2-phenylchromen-4-one. They were evaluated for antioxidant activity and antibacterial activity against the Gram-positive and Gram-negative bacteria. Five test compounds exhibited DPPH radical scavenging activity with IC 50 below 100 lg/ml, and the same test compounds exhibited 50-100% growth inhibition in Gram-positive bacteria against standard Amoxicillin.

Antimicrobial Activity of Flavone Analogues

“…In current era, the derivatives of synthesized compounds (Flavonoids) have been associated with various pharmacological activities such as, antibacterial, antioxidant, anticancer, anti-diabetic [14,25]. The 3-methyl flavanones and 3-hydroxy flavones may become the probable potential class of compounds for future study.…”

“…A very few reports are available to the substitution pattern in ring C at 3-position. However 3-hydroxy flavones and 3-methyl flavones have been synthesized by many researchers [5,14], but their further reductions at 2,3-position in ring C are rare and yet to be explored. Substitution pattern at 3-position of ring C mainly regulates bioavailability and metabolism [15,16].…”

Design, synthesis, and spectroscopic study of some new flavones containing two azo linkages

“…Flavones are also known as (2-phenylchromones) are natural compounds related to the flavonoid family [3], Flavones display a part of largest groups of natural products that widely distributed in nature [4]. Flavones display a wide spectrum of biological activity for instance, antioxidant activity [5], antifungal [6], Anti-Tuberculosis Agents [7], antibacterial activity [8], anticancer agents [9], anti-inflammatory agents [10], antimalarial [11]. Flavones can be prepared by different methods such as Baker Venkatraman rearrangement [12], Allan -Robinson [13] and traditional method Claisen -Schmidt condensation reaction followed by oxidative cyclization with DMSO/I 2 [14] CsF with CaO [15] or Oxalic aicd/ethanol [16].…”

Comparative studies on Synthesis of 2-Chloro-N-(2, 5-Dihydro-1, 3, 4-Thiadiazol-2-Yl) Acetamide using Microwave irradiation and Conventional techniques and their Antioxidant activity

“…Such assays can be of great importance in determining biochemical properties of various chemical compounds that may further aid in the characterization of the compounds. [10] II.…”