Synthesis of 3-methyl-6-r-6h-thiazolo-[4,3-b]-1,2,4-triazolo[4,3-d]-1,3,4-thiadiazoles

Kukaniev, M. A.; Akbarova, M. M.; Сангов, З. Г.; Safarov, Sayfidin; Osimov, D. M.

doi:10.1007/s10593-010-0552-8

Cited by 7 publications

(2 citation statements)

References 4 publications

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“…For our investigation, we chose chloro‐functionalized benzothiazolo[3,2‐ a ]pyrimidin‐4‐one 1 as a readily available starting material . Compound 1 was synthesized by condensation of commercially available 2 ‐ amino ‐ 6 ‐ chlorobenzothiazole with ethyl acetoacetate (Scheme ) …”

Section: Resultsmentioning

confidence: 99%

Synthesis of Novel Benzothiazolo[3,2‐a]pyridimidin‐4‐ones with Potential Cytotoxic and Pro‐Apoptotic Potential

et al. 2018

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The combination of cyclocondensation with palladium catalysed cross‐coupling reactions, afforded a variety of 8‐functionalized benzothiazolo[3,2‐a]pyridimidin‐4‐ones in good to excellent yields. The anti‐proliferative potential of the synthetic compounds was evaluated in human cervical adenocarcinoma cells (HeLa) and hamster normal fibroblasts (BHK‐21). Three of the test derivatives exhibited the strongest cytotoxicity in HeLa cells with the median inhibitory concentration (IC50) of 0.93, 1.55 and 1.84 μM, respectively. Moreover, their anti‐proliferative effect was three times less strong in normal fibroblasts, asserting their possible anti‐cancer potential.

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Section: Resultsmentioning

confidence: 99%

Synthesis of Novel Benzothiazolo[3,2‐a]pyridimidin‐4‐ones with Potential Cytotoxic and Pro‐Apoptotic Potential

et al. 2018

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“…Small ring heterocycles containing hetero‐atom such as nitrogen, sulfur, and oxygen have been under investigation for a long time because of their important medicinal properties. Among this type of molecules, 1,3,4‐thiadiazoles were shown to have various important pharmaceutical activities such as antibacterial, antifungal, antiviral, diuretic, tuberculostatic, anti‐HIV, antihistaminic, anticancer, antihypertensive, antimicrobial, antitubercular, anticonvulsant, anti‐inflammatory, antioxidant, antidiabetic, antihepatitis B viral, Central nervous system (CNS) depressant, and analgesic activities .…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Antimicrobial Evaluation of Some Novel 5‐Phenyl‐5H‐thiazolo[4,3‐b][1,3,4]thiadiazole Systems

Hamama

Ibrahim

Raoof

et al. 2017

Journal of Heterocyclic Chem

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Condensation of 2‐amino‐5‐phenyl‐5H‐thiazolo[4,3‐b] [1,3,4] thiadiazoles (1) with some carboxylic acid derivatives furnished corresponding compounds 2–4, respectively. Alkylation of 1 with benzoylchloride and 4‐chlorobenzyl chloride afforded thiazolo[4,3‐b][1,3,4]thiadiazole derivatives 5 and 6, respectively. Similarly, transformation of 1 with chloroacetyl chloride yielded chloroacetamide derivative 7. The later compound was subjected to react with potassium thiocyanate or piperazine whereby, the binary thiazolidinone derivative 8 and N1,N4‐disubstituted piperazine 9 were produced, respectively. Also, the reactivity of 1 toward various active methylene reagents was investigated. Accordingly, our attempts to synthesize the tricyclic heterocyclic system 10, 11′, 12′ by reaction of 1 with chloroacetonitrile, 4‐oxo‐4‐phenylbutanoic acid and/or diethylmalonate in presence of acetyl chloride was furnished 10, 11, and 12. The newly synthesized compounds were screened as antimicrobial agent.

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ChemInform Abstract: Synthesis of 3‐Methyl‐6‐R‐6H‐thiazolo[4,3‐b]‐1,2,4‐triazolo [4,3‐d]‐1,3,4‐thiadiazoles (IV).

et al. 2011

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Synthesis of 3-methyl-6-r-6h-thiazolo-[4,3-b]-1,2,4-triazolo[4,3-d]-1,3,4-thiadiazoles

Cited by 7 publications

References 4 publications

Synthesis of Novel Benzothiazolo[3,2‐a]pyridimidin‐4‐ones with Potential Cytotoxic and Pro‐Apoptotic Potential

Synthesis of Novel Benzothiazolo[3,2‐a]pyridimidin‐4‐ones with Potential Cytotoxic and Pro‐Apoptotic Potential

Synthesis and Antimicrobial Evaluation of Some Novel 5‐Phenyl‐5H‐thiazolo[4,3‐b][1,3,4]thiadiazole Systems

ChemInform Abstract: Synthesis of 3‐Methyl‐6‐R‐6H‐thiazolo[4,3‐b]‐1,2,4‐triazolo [4,3‐d]‐1,3,4‐thiadiazoles (IV).

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