Synthesis of 3′H-spiro[cyclohexane-1,1′-isobenzofuran]-2,5-dien-4-one and Skeleton construction of a type D spirobisnaphthalene structure via dearomatization by a high-valence iodine reagent and Diels–Alder reaction

Abstract

The core skeleton syntheses 3’H-spiro[cyclohexane-1,1’-isobenzofuran]-2,5- dien-4-one and their derivatives (3a-3w) of spirobisnaphthalene urnucratins, plecmillins and lignan kadsulignan, were explored using the Suzuki–Miyaura coupling product biphenols as the precursors and the...