Synthesis of 3-cyano-2-fluoropyridines

Synthesis of new fluorescent molecules having an aggregation-induced emission property derived from 4-fluoroisoxazoles

“…The importance of fluorinated heterocyclic derivatives in the pharmaceutical and agrochemical industries continues to grow, with several fluorinated 6-membered heteroaromatic derivatives finding applications in a wide variety of drugs and plantprotective agents [15][16][17][18][19][20][21][22][23][24][25][26][27]. However, there are only a few reports on the synthesis and properties of fluorinated 5-membered heteroaromatic systems, especially those comprising two heteroatoms such as pyrazoles [28,29], isoxazoles [30], and thiazoles [31,32].…”

Synthesis of new fluorescent molecules having an aggregation-induced emission property derived from 4-fluoroisoxazoles

“…On the other hand, many fluorinated 6-membered heteroaromatic derivatives find applications in a wide variety of drugs and plant protective materials and, consequently, there are several examples of the synthesis of fluorinated 6-membered heteroaromatic rings by selective fluorination strategies. [15][16][17][18][19][20][21][22][23][24][25][26][27] However, selective fluorination of 5membered heteroaromatic systems are rare and, in particular, there are only a few reports concerning the synthesis of fluorinated 5-membered heteroaromatic systems that have two heteroatoms, such as pyrazoles [28,29], isoxaoles [30] and thiazoles [31,32]. We recently reported selective fluorination of isoxazoles to give mono-fluorinated isoxazoles (3) or tri-fluorinated isoxazolines (4) in moderate to good yields (Scheme 1).…”

Reaction of hydroxylated naphtoquinones/antraquinones with pentafluoropyridine

“…In pharmacology and medicinal researches, it is common to substitute hydrogen with fluorine atom for increasing the lipophilicity and the biological activity of drugs (Anatoliy et al 2009). Various multi-functional pyridine derivatives and the construction of new heterocyclic drug systems could be accessed from the high electron efficiency of pentafluoropyridine and appropriate nucleophile in simple reaction conditions (Satoru et al 2006; Cindy et al 2010).…”