Abstract:3-chloro-2-oxo-butyric acid ethyl ester 5 is an important intermediate in many biologically active compounds such as thiazole carboxylic acids. In this work, a rapid synthetic method for compound 5 was established. The compound 5 was synthesized from the commercially available diethyl oxalate through two steps including nucleophilic substitution, chlorinated. The structure was confirmed by MS and 1 HNMR. Furthermore, the synthetic method was optimized. The total yield of the two steps was30%
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.