Synthesis of 3-Carboethixy-4-oxo-4H-pyrimido[1',2':1,5][1,2,4]triazolo[3,4-b]benzoxazole and 5H-Pyrido[3",2":5',6']pyrimido[1',2':1,5][1,2,4]triazolo[3,4-b]benzoxazole-5-one: Novel Heterocycles

Synthesis and Antifungal Activities of Some New 5,7‐Disubstituted[1,2,4]Triazolo[1,5‐a]Pyrimidin‐6‐one Derivatives

“…In this system a part of the heterocyclic moiety (1,2,4-triazole) is incorporated with the Schiff base comprising a heterodiene system and attribute as 4π component in Diels-Alder reactions. [4 + 2] cycloaddition reaction was carried out by dropwise addition of a solution of phenylacetyl chloride or diphenylacetyl chloride in dry 1,4-dioxan to a cold, stirred solution of 3benzylidineamino [1,2,4]triazole in dry 1,4-dioxan and triethylamine for a period of 30 min. After the complete addition of acid chloride, the reaction mixture was stirred for a further period of 8 h at 80°C (Fig.…”

“…Cultures of the test fungi were grown on PDA for 7 days at Figure 1. Synthesis of 5,7-Disubstituted [1,2,4] triazolo [1,5-a] pyrimidin-6-one derivatives by [4+2] cycloaddition reaction. Table 1 Physical data of 5,7-diaryl- [1,2,4]-triazolo [1,5-a]pyrimidin-6-one (3a-g)and 5,5,7-triaryl- [1,2,4]-triazolo [1,5-a]pyrimidin-6-one(4a-g).…”

“…3-Benzylidineaminotriazole was prepared following literature procedure [10]. Synthesis of 5,7-diaryl- [1,2,4]-triazolo [1,5-a]pyrimidin-6-one (3a-g).…”

“…A variety of 1,2,4-triazole derivatives have been described as having biological activities including antidepressive, anti-inflammatory, antibacterial, antifungal, and insecticidal properties [9]. In light of these facts we have synthesized some new 5,7diphenyl- [1,2,4]-triazolo [1,5-a]pyrimidin-6-one derivatives and 5,5,7-triphenyl-[1,2,4]-triazolo [1,5-a]pyrimidin-6-one from 3-benzylidineamino- [1,2,4]-triazole [10] and phenyl ketene and diphenyl ketene generated in situ, by a [4 + 2] cycloaddition reaction and screened these compounds for their antifungal activities.…”

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in Wiley Online Library (wileyonlinelibrary.com). [1,2,4]triazolo[1,5-a]pyrimidin-6-one by [4 + 2]cycloaddition reaction of 3-benzylidineamino[1,2,4]triazole with monophenyl ketene and diphenyl ketene generated in situ from phenylacetyl chloride and diphenylacetyl chloride in the presence of triethylamine is described. The newly synthesized compounds were also tested for antifungal activities against Rhizoctonia solani and Trichoderma sp.

Synthesis of a new series of

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