Synthesis of 3‐(6‐R‐Benzothiazol‐2‐yl)‐4‐methyl‐1,2,5‐oxadiazoles.

Abstract

Oxadiazole derivatives R 0290Synthesis of 3-(6-R-Benzothiazol-2-yl)-4-methyl-1,2,5-oxadiazoles. -A high-yielding three-step procedure for the synthesis of oxadiazoles (IV) is developed. The benzothiazole ring formation proceeds simultaneously during nitrosation of the activated methylene group in the starting compound (I). -(BRITSUN, V. N.; BORISEVICH, A. N.; SAMOILENKO, L. S.; LOZINSKII, M. O.; Russ. J. Org. Chem. 41 (2005) 5, 745-747; Inst. Org. Chem., Acad. Sci. Ukr., Kiev 253094, Ukraine; Eng.) -R. Staver 51-115