Synthesis of 3,6‐Disubstituted 4‐Ethoxycarbonylpyranoindol‐1‐ones Utilizing 3‐Amino‐2‐pyrone Synthesis

Abstract

Synthesis of 3,6-disubstituted 4-ethoxycarbonylpyranoindol-1-ones is developed using palladium-catalyzed intramolecular amination of 3-amino-4-(2-bromophenyl)-2-pyrones prepared by the conjugate addition reaction of diethyl 2-aminomalonate to alkynyl ketones. The