Synthesis of 3‐[5‐methyl‐1‐(4‐methylphenyl)‐1,2,3‐triazol‐4‐yl]‐6‐substituted‐s‐triazolo[3,4‐b]‐1,3,4‐thiadiazoles

He, Dong; Wang, Qinglian; Quan, Bin; Zhang, Ziyi

doi:10.1002/jccs.200000044

Cited by 16 publications

(4 citation statements)

References 4 publications

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“…[18][19][20] Elemental analyses were performed on a Thermo Flash EA-1112 analyzer. The ligand 5-methyl-1-(4methylphenyl)-1,2,3-triazol-4-carboxylic acid (HL) was synthesized according to a literature procedure.…”

Section: Materials and General Methodsmentioning

confidence: 99%

Syntheses and Crystal Structures of Copper(II) and Silver Complexes with 5‐Methyl‐1‐(4‐Methylphenyl)‐1,2,3‐Triazol‐4‐Carboxylic Acid

Wu¹,

Wang²,

Cao³

2009

J Chinese Chemical Soc

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Two novel complexes [CuL2(MeOH)] (1)and [Ag2L(HL)2(MeOH)] (2) (L = 5‐methyl‐1‐(4‐methylphenyl)‐1,2,3‐triazol‐4‐carboxylic acid) were synthesized and characterized by elemental analysis, IR and X‐ray diffraction. Complex 1 is a mononuclear structure; the molecules were assembled into an infinite 2–D supramolecular by the C–H···O weak interactions. Complex 2 is a centrosymmetric dinuclear structure with bis(unidentate) carboxylato co‐ordination mode, and the molecules were assembled into 2–D layers by C–H···O and O–H···O weak interactions.

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Section: Materials and General Methodsmentioning

confidence: 99%

Syntheses and Crystal Structures of Copper(II) and Silver Complexes with 5‐Methyl‐1‐(4‐Methylphenyl)‐1,2,3‐Triazol‐4‐Carboxylic Acid

Wu¹,

Wang²,

Cao³

2009

J Chinese Chemical Soc

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“…(17,18) like compound (19,20) . Abo-Orabi (21) , synthesized several triazole derivatives through 1,3-dipolar cycloaddition reactions of substituted…”

Section: 23-triazolementioning

confidence: 99%

Physical Properties of Cyclestructure

2019

aijbls

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Azo – cyclic derivatives are a part from a ring that has more than type of atoms. Nitrogen, oxygen and sulfur are often found along with carbon in heterocycles rings. Heterocycles derivatives are common in chemical chemistry, and many have fulfilled important physiological active in plant and animal kingdoms and have an important biological properties, such as, the antibiotic penicillin, sedative phenabarbital, and sugar replacing reagent saccharin, all having heterocycles ring.

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“…However, there are few of researches on the synthesis and inflammatory activity of murrayafoline A derivatives (Cuong et al 2008). Otherwise, a wide variety of pharmacological properties have been shown to be associated with 1,2,3-and 1,2,4-triazole nucleus (Choi et al 2010) which including antibacterial (Prakash et al 2004;Sztanke et al 2006), antifungal (Lebouvier et al 2007;Liu et al 2008), antioxidant (Kamotra et al 2007), anticancer (Sztanke et al 2008), anticonvulsant (Almasirad et al 2004), analgesic (Gilani et al 2008), antiviral (De Clercq 2002Dong et al 2000), and anti-inflammatory (Buckler et al 1978;Shafi et al 2012) activities. Recently, the synthesis, anti-bacterial and antifungal activities of imidazole and 1,2,4-triazole-based N-substituted carbazole derivatives have been reported (Zhang et al 2010).…”

Section: Introductionmentioning

confidence: 99%

Synthesis of novel derivatives of murrayafoline A and their inhibitory effect on LPS-stimulated production of pro-inflammatory cytokines in bone marrow-derived dendritic cells

et al. 2013

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A series of N-substituted-1,2,3-triazole murrayafoline A derivatives were successfully synthesized using click azide-alkyne Huisgen cycloaddition reaction between 1-methoxy-3-methyl-9-(3-azido)-propyl-9H-carbazole and substituted alkynes. Their chemical structures were confirmed by (1)H, (13)C NMR and HR-ESI-MS spectral data. In addition, the interested effects on LPS-stimulated production of pro-inflammatory cytokines in bone marrow-derived dendritic cells of synthetic murrayafoline A derivatives were also investigated. Our results indicated that murrayafoline A derivatives containing 1,2,3-triazole nucleus potentially possessed anti-inflammatory action through inhibiting production of IL-6, IL-12 p40 and TNF-α.

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Synthesis of 3‐[5‐methyl‐1‐(4‐methylphenyl)‐1,2,3‐triazol‐4‐yl]‐6‐substituted‐s‐triazolo[3,4‐b]‐1,3,4‐thiadiazoles

Cited by 16 publications

References 4 publications

Syntheses and Crystal Structures of Copper(II) and Silver Complexes with 5‐Methyl‐1‐(4‐Methylphenyl)‐1,2,3‐Triazol‐4‐Carboxylic Acid

Syntheses and Crystal Structures of Copper(II) and Silver Complexes with 5‐Methyl‐1‐(4‐Methylphenyl)‐1,2,3‐Triazol‐4‐Carboxylic Acid

Physical Properties of Cyclestructure

Synthesis of novel derivatives of murrayafoline A and their inhibitory effect on LPS-stimulated production of pro-inflammatory cytokines in bone marrow-derived dendritic cells

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