Synthesis of 3,5-disubstituted 1,2,4-oxadiazoles using ionic liquid-phase organic synthesis (IoLiPOS) methodology

Application of ionic liquid for extraction and separation of bioactive compounds from plants

“…The problems of the adrenergic amines separation, such as band tailing, low retention and low resolution were solved using an IL. 4 ]. The sensitivity, accuracy and reproducibility of this method were satisfactory.…”

“…Qi 4 ] were used as modifiers to improve the separation efficiency and selectivity. The research showed that increasing the applied electric field strengths not only reduced the analysis time, but also did not induce excessive Joule heating in the capillary when ILs were used as modifiers.…”

“…Accordingly, ILs are known as "designer solvents", and have developed rapidly from their initial use as electrolytes in battery applications since the 1970s [3]. Currently, ILs are being applied in every branch of chemistry including organic chemistry, inorganic chemistry, biochemistry, physical chemistry and analytical chemistry [4][5][6][7][8]. The interest of ILs in analytical chemistry has grown quickly over many years and a wide range of applications of ILs in analytical chemistry has been reported [9][10][11][12][13][14].…”

1,2,4-oxadiazole: A Brief Review from the Literature About the Synthesis and Pharmacological Applications

“…The basic concept behind these developments is that the 1,2,4-oxadiazole ring is a bioisosteric alternative of hydrolysis resistant to one molecule of ester or amide [20], and one better performance in vivo is often observed due to the metabolic stability of the oxadiazole ring in the aqueous medium within the complete range of pH to the climate temperature (ISPIKOUDI et al, 2010). The bioisosteric replacement of an amide portion represents a center focus because of its implications in peptide chemistry and development of peptidomimetics, which are being explored in large part to contour some of the disadvantages of native peptides and to increase the bioavailability and potency of drugs based on peptide, furthermore, the core 1,2,4-oxadiazole is the structural core unit of the muscarinic agonist (DUCHET et al, 2010).…”

Ionic liquids in supported liquid membrane technology

“…The properties of the ILs can significantly change by varying the length of the alkyl groups that are incorporated into the cation and the types of anions. ILs are widely considered as alternatives to classical organic solvents and as such have been applied in many fields such as organic synthesis, electrochemistry, liquid phase extraction, catalysis for clean technology and polymerization processes [46][47][48][49][50]. Accordingly, their applications in separation technology have attracted great attention.…”