Synthesis of 3,3′‐Disubstituted Isobenzofuran‐1(3H)‐Ones via Cs0.5H2.5PW12O40‐Catalyzed Difunctionalization of Carbonyls

Liu, Yufeng; Cao, Gang-Ming; Chen, Lei; Li, Ké; Lin, Xiaoling; Xu, Xinxin; Zhanggao, Le; Yang, Guo‐Ping

doi:10.1002/adsc.202200081

Cited by 12 publications

(5 citation statements)

References 54 publications

(5 reference statements)

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“…Denaturation of proteins in the synovial membrane and surrounding tissues is a well-known trigger of arthritic conditions. Some forms of arthritis might generate autoantigens because of protein denaturation 28,55 . By altering electrostatic, hydrophobic, hydrogen, and disulfide bonds in proteins, lysosomal lysis during inflammation may contribute to denaturation 55 .…”

Section: Discussionmentioning

confidence: 99%

Phytochemical Studies, Anti-Oxidant and Anti- Inflammatory Properties of Four Medicinal Plants

Sharma,

Goel

2023

JEOH

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Rheumatoid arthritis, a chronic autoimmune disorder, is characterized by polyarthralgia and joint dysfunction resulting from autoimmune responses that target self-neoepitopes. These attacks lead to the activation of macrophages and other defense cells. By identifying these self-epitopes as biomarkers in RA, researchers have gained valuable insights into the disease’s pathogenesis. Over the years, research has focused on investigating the potential of medicinal plants as antiinflammatory agents. In this study, a hydroethanolic extract of Saraca asoca, Ficus benghalensis, Chenopodium album, and Nyctanthes arbor-tristis leaves was prepared by Soxhlet apparatus. Various concentrations of extracts were utilized to assess phytochemical analysis, GC-MS, in-vitro anti-oxidant, and anti-inflammatory activities. The highest scavenging potential was exhibited by Chenopodium album, as assessed by the DPPH assay (90.32 ± 3.2 %) and H2O2 (86.00 ± 1.94 %). Similarly, the Nyctanthes arbor-tristis showed (92.23 ± 0.83 %) inhibition in membrane stabilization assay, and (91.49 ± 1.03 %) in protein denaturation inhibition capacity. GCMS analysis showed various phytoconstituents in extracts. In order to confirm its therapeutic potential for treating RA, Nyctanthes arbor-tristis may be a better drug candidate that needs to be further researched for mechanistic studies.

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Section: Discussionmentioning

confidence: 99%

Phytochemical Studies, Anti-Oxidant and Anti- Inflammatory Properties of Four Medicinal Plants

Sharma,

Goel

2023

JEOH

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“…Many heterogeneous materials based on HPAs have been developed to overcome these limitations. A common strategy is the modification of polyanions with inorganic ions (such as Cs + , Mg 2+ , Cu 2+ ) [74][75][76] or organic compounds (such as ionic liquids (ILs) and organic sulfonic acids) [77][78][79] as counter cations to synthesize insoluble compounds. The introduction of transition metals not only reduces the solubility of HPAs but also provides additional Lewis acid active sites.…”

Section: Cation-functionalized Hpa Catalystsmentioning

confidence: 99%

Polyoxometalate catalysts for the synthesis of N-heterocycles

Hu,

Li,

Chen

et al. 2024

Polyoxometalates

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N-Heterocycle compounds are crucial scaffolds in natural products, synthetic molecules, agricultural chemicals, and pharmaceuticals. Hence, green catalytic systems for the synthesis of N-heterocycles have been widely researched in organic synthesis and industrial catalysis. Polyoxometalates (POMs) are polynuclear metal-oxygen clusters with diverse structures and physicochemical properties. POMs exhibit multiple advantageous properties such as adjustable acidity, redox properties, high thermal stability, and nontoxic nature. Therefore, POMs have been widely investigated for their application in N-heterocycles synthesis and held great potential for industrial applications. In this review, we summarize recent advances (mainly from 2010 to 2023) in the synthesis of N-heterocycles, such as pyrroles, indoles, pyridines, and benzodiazepines, catalyzed by heteropolyacids (HPAs), modified HPA catalysts, and transition metal-modified POMs. The prospects of POM-based catalytic systems for the synthesis of N-heterocycles are also outlined.

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“…Recently, Yang's group reported a novel method to construct 3,3'-disubstituted phthalides viaCs 0.5 H 2.5 PW 12 O 40 -catalyzed difunctionalization of carbonyls (Scheme 3). [13] This method allows forming the quaternary carbon while building the lactone frameworks. A range of nucleophiles were reacted with 2-acylbenzoic acids to furnish the functionalized phthalides with a good yield range of 61-96%.…”

Section: Scheme 2 Synthesis Of Phthalidesmentioning

confidence: 99%

Recent Advances in the Synthesis of Heterocycles from 2-Acylbenzoic Acids

Liu,

Li,

Yang

2024

Preprint

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Heterocyclics are the crucial scaffolds present in pharmaceuticals, natural products, biologically active compounds and agrochemicals. Consequently, the development of simple and practical methods for constructing heterocyclics has always been a fascinating field in organic synthesis. Recently, 2-acylbenzoic acids as highly reactive and versatile synthons have been broadly applied in the construction of heterocycles due to their multiple reaction sites. In this review, we summarized recent progress in the application of 2-acylbenzoic acids for the synthesis of heterocycles including phthalides, isochromanones, isoindolines, phthalazinones, and quinolones. The sub-strate scopes, proposed mechanisms, and product application of different types of reactions are discussed.

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Synthesis of 3,3′‐Disubstituted Isobenzofuran‐1(3H)‐Ones via Cs_0.5H_2.5PW₁₂O₄₀‐Catalyzed Difunctionalization of Carbonyls

Cited by 12 publications

References 54 publications

Phytochemical Studies, Anti-Oxidant and Anti- Inflammatory Properties of Four Medicinal Plants

Phytochemical Studies, Anti-Oxidant and Anti- Inflammatory Properties of Four Medicinal Plants

Polyoxometalate catalysts for the synthesis of N-heterocycles

Recent Advances in the Synthesis of Heterocycles from 2-Acylbenzoic Acids

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