Abstract:2'-Modified inosine analogs have been synthesized from 6-chloropurine riboside via 6-dimethylaminopurine or 6-benzyloxypurine intermediates. The dimethylaminopurine intermediate was obtained via an unusually facile dimethylamine transfer from dimethylformamide. Graphical Abstract:
2′‐Modified inosine analogues (V) and (X) are synthesized from 6‐chloropurine riboside (I) via 6‐(dimethylamino)purine (IV) or 6‐(benzyloxy)purine (VIII) intermediates.
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