Synthesis of 2‐Phenyl‐4,6‐bis(trifluoromethyl)pyridine
via
NH
4
I/Na
2
S
2
O
4
‐Mediated Cyclization of Ketoxime Acetates
Huawen Huang,
Zhenhua Xu,
Guo‐Jun Deng
Abstract:This chapter presents the procedure for synthesis of 2‐phenyl‐4,6‐ bis(trifluoromethyl) pyridine via NH
4
I/Na
2
S
2
O
4
‐ mediated cyclization of ketoxime acetates. O‐Acyl oximes have been used as versatile building blocks to form N‐containing heterocycles through catalytic N–O bond reduction by transition metal‐mediated oxidative addition. In this work, the authors have developed a NH
4
I/N… Show more
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