Synthesis of 2-Amino-4-(2-hydroxynaphthyl)-4H-chromene-3-carbonitriles by Michael Addition and Their Transformation into New Pentacyclic Compounds

Dammak, Lamia; Kammoun, Myriam; Ammar, Houcine; Abid, Souhir; Gharbi, Rachid El

doi:10.1080/00397911.2014.924142

Cited by 8 publications

(2 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…2-Amino-4-(2-hydroxynaphthyl)-8-methoxy-4H-chromene-3-carbonitrile 1 was prepared as previously described 18 . All reagents were purchased from commercial sources and used without further purification.…”

Section: Chemistrymentioning

confidence: 99%

“…Moreover, they are convenient synthons in the synthesis of densely substituted nitrogen heterocycles displaying remarkable effects as pharmaceuticals, which justifies our continuing efforts in designing novel heterocyclic molecules of biological importance. In this context, our team in a recent study investigated a facile route for the formation of novel 2-amino-4-(2-hydroxynaphthyl)-4H-chromene-3-carbonitriles via Michael addition of various 3-cyanoiminocoumarins and β-naphthol 18 . We found that these compounds are convenient starting materials to provide various polyheterocyclic systems.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Synthesis and antibacterial activity of 2-amino chromenes arising cyanoiminocoumarins and β-naphthol

Dammak¹,

Kammoun²,

Allouche³

et al. 2017

Org. Commun.

Self Cite

View full text Add to dashboard Cite

Abstract:The synthesis of 2-amino chromene, reported in our previous paper, has been accomplished by the reaction of cyanoiminocoumarin and β-naphthol. The obtained compound was reacted with various electrophilic or nucleophilic reagents. All the new homologous 2-amino-4H-chromenes have been characterized on the basis of their spectral (IR, 1 H and 13 C NMR) data and microanalysis. Four compounds were evaluated in vitro for their preliminary antibacterial activities against five different pathogenic bacterial strains such as Bacillus thuringiensis, Escherichia coli, Staphylococcus aureus, klebsiella pneumonia and Salmonella Sp. Antibacterial activity of each compound was compared with standard drug, Penicillin.

show abstract

Section: Chemistrymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%