Synthesis of 2-amidoindenone derivatives through an ynamide carbosilylation/Houben–Hoesch cyclization 2-step sequence

Abstract

A simple and selective two-step sequence is reported for the synthesis of polyfunctionalized 2-amidoindenones. Remarkably, this method achieves true structural diversity at position 3.

Nickel-catalysed regio- and stereoselective hydrocyanation of alkynoates and its mechanistic insights proposed by DFT calculations

“…To control the above selectivity, structural modification using heteroatoms on the C–C triple bonds has been investigated. For example, the steric bulk of silyl groups 12 and the electronic effects on N- 13 and O-functionalities 14 can all be applied to regio- and stereoselective cyanation. Recent applications involve the use of the conjugated enynes 15 a , b and diynes 15 c as non-symmetric internal alkynes.…”