CNRS n'458, 8 rue de 1'Ecole Normale, 34053 Montpellier Cedex 1 (France).Abstract: Reaction of (f)but-3-en-l,2-diol (3) with ethyl diazoacetate afforded two cyclopropyl compounds ( 5 ) and (6). Their relative rruns stereochemistry at C-2 and C-3 has been determined by high-field and computational NMR spectroscopy.
(+)Trans-1-( 1',5'-dihydroxy-3',4'-methylenyl-pent-2'-oxy)methyl]thymine (Id) or -cytosine (lb) and(+)rrcms-9-(1',5'-dihydroxy-3',4'-methylenylpent-2'-oxy)-methylladenine (la) or -guanine (lc) have been obtained through a regiospecific alkylation procedure and their antiviral evaluation is reported.