Synthesis of [2.2]Paracyclophane-Fused Heterocycles via Palladium-Catalyzed C–H Activation/Annulation of [2.2]Paracyclophanecarboxamides with Arynes
Chongqing Pan,
Hongwei Sun,
Yonglei Du
et al.
Abstract:Metrics & MoreArticle Recommendations * sı Supporting Information ABSTRACT: [2.2]Paracyclophane-fused heterocycles represent an important scaffold. Traditional approaches often suffer from tedious synthetic routes, and the development of catalytic synthesis of them remains in its infancy. Herein, by employing highly strained aryne intermediates as partners, we have developed a concise protocol by palladium-catalyzed C−H activation/annulation from [2.2]paracyclophanecarboxamide substrates. [2.2]Paracyclophane-f… Show more
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