Synthesis of 198Au nanoparticles sub 10 nm due optimization on local dose by Monte Carlo simulations for cancer treatment

Villate, Julián Mateo Zutta; Rojas, Jessika V.; Hahn, Marc Benjamin; Puerta, J. A.

doi:10.1007/s10967-022-08355-5

Cited by 2 publications

(1 citation statement)

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“…Currently, many nanoparticle related studies focus on gold nanoparticles (AuNPs) This is due to the fact that cellular uptake of AuNPs takes place for diameters up to some tens of nanometers [242]. They are evaluated for different types of therapies, such as external beam therapy [243,244], in brachytherapy [245], for photothermal therapy in combination with pulsed laser sources [231,246], and as radioactive nanoparticles [234,[247][248][249][250]. To obtain a detailed understanding of the radiosensitizing mechanisms, the kinetic energy spectrum of secondary particles emitted from the nanoparticle surface and the spatially resolved energy deposit have to be studied.…”

Section: Radiosensitizermentioning

confidence: 99%

Accessing radiation damage to biomolecules on the nanoscale by particle-scattering simulations

Hahn

2023

J. Phys. Commun.

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Radiation damage to DNA plays a central role in radiation therapy to cure cancer. The physico-chemical and biological processes involved encompass huge time and spatial scales. To obtain a comprehensive understanding on the nano and the macro scale is a very challenging tasks for experimental techniques alone. Therefore particle-scattering simulations are often applied to complement measurements and aide their interpretation, to help in the planning of experiments, to predict their outcome and to test damage models. In the last years, powerful multipurpose particle-scattering framework based on the Monte-Carlo simulation (MCS) method, such as Geant4 and Geant4-DNA, were extended by user friendly interfaces such as TOPAS and TOPAS-nBio. This shifts their applicability from the realm of dedicated specialists to a broader range of scientists. In the present review we aim to give an overview over MCS based approaches to understand radiation interaction on a broad scale, ranging from cancerous tissue, cells and their organelles including the nucleus, mitochondria and membranes, over radiosensitizer such as metallic nanoparticles, and water with additional radical scavenger, down to isolated biomolecules in the form of DNA, RNA, proteins and DNA-protein complexes. Hereby the degradation of biomolecules by direct damage from inelastic scattering processes during the physical stage, and the indirect damage caused by radicals during the chemical stage as well as some parts of the early biological response is covered. Due to their high abundance the action of hydroxyl radicals (•OH) and secondary low energy electrons (LEE) as well as prehydrated electrons are covered in additional detail. Applications in the prediction of DNA damage, DNA repair processes, cell survival and apoptosis, influence of radiosensitizer on the dose distribution within cells an their organelles, the study of linear-energy-transfer (LET), the relative-biological-effectiveness (RBE), ion-beam cancer-therapy, microbeam-radiation-therapy (MRT), the FLASH effect, and the radiation induced bystander effect are reviewed.

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