Synthesis of [18F]2-deoxy-2-fluoro-d-glucose from highly reactive [18F]tetraethylammonium fluoride prepared by hydrolysis of [18F]fluorotrimethylsilane

Hutchins, Larry G.; Bosch, A.L.; Rosenthal, M.S.; Nickles, Robert J.; Gatley, S.J.

doi:10.1016/0020-708x(85)90277-7

Cited by 25 publications

(2 citation statements)

References 11 publications

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“…Naturally, the acetonitrile content estimation does not come into consideration by the organic solvents applied for LC and GC should stay as the complementary methods. As for behaviour of [laF]fluoride it can be normally eluted in a void volume from a C18 silica column and detected by radiometric detector, however substantial portion can be retained in sampling syringe and on amino columns [8].…”

Section: Introductionmentioning

confidence: 99%

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HPLC-MS technique for radiopharmaceuticals analysis and quality control

Macášek¹,

Buriova²,

Brúder

et al. 2003

Czech J Phys

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Potentialities of liquid chromatography with mass spectrometric detector (MSD) were investigated with the objective of quality control of radiopharmaceuticals; 2-deoxy-2-[ lsF]fluoro-D-glucose (FDG) being an example. Screening of suitable MSD analytical lines is presented. Mass-spectrometric monitoring of acetonitrile -aqueous ammonium formate eluant by negatively charged FDG.HCO 2-ions enables isotope analysis (specific activity) of the radiopharmaceutical at m/z 227 and 226. Kryptofix | 222 provides an intense MSD signal of the positive ion associated with NH4 § at m/z 394. Expired FDG injection samples contain decomposition products from which at least one labelled by 18F and characterised by signal of negative ions at m/z 207 does not correspond to FDG fragments but to C 5 decomposition products. A glucose chromatographic peak, characterised by m/z 225 negative ion is accompanied by a tail of a component giving a signal of m/z 227, which can belong to [1SO]glucose; isobaric sorbitol signals were excluded but FDG-glucose association occurs in the co-elution of separation of model mixtures. The latter can actually lead to a convoluted chromatographic peak, but the absence of 18F makes this inconsistent. Quantification and validation of the FDG component analysis is under way.

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Section: Introductionmentioning

confidence: 99%

“…13,16,21,24-hexaoxa-l,lO-diazabicyclo(8,8,8)-hexacosane applied to the column. For the analysis of expired [18F]FDG injection (IJJF i~e~), the samples were diluted by this solvent before analysis.…”

mentioning

confidence: 99%

HPLC-MS technique for radiopharmaceuticals analysis and quality control

Macášek¹,

Buriova²,

Brúder

et al. 2003

Czech J Phys

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Recent Developments in the Chemistry of [¹⁸F]Fluoride for PET

Roeda

Dollé

2014

The Chemistry of Molecular Imaging

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Siliciumbausteine für eine einstufige ¹⁸F‐Radiomarkierung von Peptiden für die PET‐Bildgebung

Höhne

Schubiger

et al. 2008

Angewandte Chemie

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Landeplatz für Fluor: Durch einen einstufigen Ansatz gelingt die einfache 18F‐Markierung von Biomolekülen über Siliciumgruppen unter milden Bedingungen (siehe Schema). Ein Di‐tert‐butylsilyl‐Derivat mit Aryllinker wurde an ein Tetrapeptid angehängt. Das Konstrukt wies eine Hydrolysebeständigkeit auf, die einen Einsatz in der Positronenemissionstomographie in vivo möglich erscheinen lässt.

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Synthesis of [18F]2-deoxy-2-fluoro-d-glucose from highly reactive [18F]tetraethylammonium fluoride prepared by hydrolysis of [18F]fluorotrimethylsilane

Cited by 25 publications

References 11 publications

HPLC-MS technique for radiopharmaceuticals analysis and quality control

HPLC-MS technique for radiopharmaceuticals analysis and quality control

Recent Developments in the Chemistry of [¹⁸F]Fluoride for PET

Siliciumbausteine für eine einstufige ¹⁸F‐Radiomarkierung von Peptiden für die PET‐Bildgebung

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Synthesis of [18F]2-deoxy-2-fluoro-d-glucose from highly reactive [18F]tetraethylammonium fluoride prepared by hydrolysis of [18F]fluorotrimethylsilane

Cited by 25 publications

References 11 publications

HPLC-MS technique for radiopharmaceuticals analysis and quality control

HPLC-MS technique for radiopharmaceuticals analysis and quality control

Recent Developments in the Chemistry of [18F]Fluoride for PET

Siliciumbausteine für eine einstufige 18F‐Radiomarkierung von Peptiden für die PET‐Bildgebung

Contact Info

Product

Resources

About

Recent Developments in the Chemistry of [¹⁸F]Fluoride for PET

Siliciumbausteine für eine einstufige ¹⁸F‐Radiomarkierung von Peptiden für die PET‐Bildgebung