Synthesis of 14C-Labeled Isomers of Dichlorodiphenyldichloroethanes(DDD)

Acid hydrolysis products of DDD and DDT precursors

“…The mass spectrum of this component showed molecular ions at m/e 168 and 170 in the correct ratio for one chlorine atom. This information was consistent for 1 -chloro-1-phenyl-2-propanone (8). In contrast to the above results, acid hydrolysis of 1 and 2 afforded no oxidative rearrangement carbonyl products.…”

Synthesis of 14C‐labelled DDD isomers of high specific activity

“…It was possible to carry 14 out the reactions in the original [ C]chlorobenzene ampoules if a small amount of solvent was permitted for the transfer of the appropriate 2,2-dichloro-l-(chlorophenyl)ethanol to the ampoule. Ultrasonic mixing of the reactants significantly improved the yields of the DDD products, even though the scale of the reaction was only 1/100 of that earlier reported (4). It was however necessary to perform the reactions in this semi-micro scale, since a high specific activity is required in,the biological work planned to be done with these DDD isomers.…”