2023
DOI: 10.1246/bcsj.20220335
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Synthesis of 11C-Radiolabeled Eribulin as a Companion Diagnostics PET Tracer for Brain Glioblastoma

Abstract: The successful 11C-radiolabeling of eribulin, an analog of the marine natural product halichondrin B, and an approved anticancer drug for the treatment of breast cancer and liposarcoma, is reported. A rapid sequence involving a nitroaldol reaction with [11C]nitromethane and subsequent reduction of the nitro group enabled the introduction of a carbon-11 atom at the C35-position of eribulin. Optimization of the reaction and purification conditions led to a reproducible synthetic method for [35-11C]eribulin with … Show more

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Cited by 7 publications
(2 citation statements)
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“…The history of the development of functional materials corresponds to the history of human progress. Even today, the development of various functional materials is still necessary to meet the demands of energy [ 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 ], the environment [ 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 ], and biomedical requirements [ 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 ]. Modern science and technology must develop materials for various functions, such as for energy production [ 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 ], energy storage [ 46 , 47 , 48 , 49 , 50 , 51 , 52 ], separation [ 53 , 54 , 55 , 56 , 57 , 58 ,…”
Section: Introductionmentioning
confidence: 99%
“…The history of the development of functional materials corresponds to the history of human progress. Even today, the development of various functional materials is still necessary to meet the demands of energy [ 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 ], the environment [ 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 ], and biomedical requirements [ 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 ]. Modern science and technology must develop materials for various functions, such as for energy production [ 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 ], energy storage [ 46 , 47 , 48 , 49 , 50 , 51 , 52 ], separation [ 53 , 54 , 55 , 56 , 57 , 58 ,…”
Section: Introductionmentioning
confidence: 99%
“…Functional materials must be created to meet these needs. These include generating energy [1][2][3][4][5][6][7], storing energy [8][9][10][11][12][13], detecting and removing environmental hazards [14][15][16][17][18][19], carbon neutrality [20][21][22][23], purifying water [24][25][26][27][28], detecting and handling viruses [29][30][31][32][33], delivering drugs [34][35][36][37][38], treating illness and injury [39][40][41][42][43][44], developing devices for these functions [45][46][47][48][49], and information conversion…”
Section: Introductionmentioning
confidence: 99%