Synthesis of 1-benzyl-4-phenyl-1H-1,2,3-triazole via Click Reaction Using [Cu(CH3CN)4]PF6 as Catalyst

Abstract

In this paper, [Cu(CH3CN)4]PF6 was used as a catalyst for the synthesis of 1-benzyl-4-phenyl-1H-1,2,3-triazole from phenylacetylene and benzyl azide via click reaction. 1-Phenyl-2-(trimethylsilyl)acetylene was synthesized via Sonogashira reaction, then the protecting group trimethylsilyl (−Si(CH3)3) was removed to obtain phenylacetylene. The structure of the obtained products was approved by modern spectroscopic methods like HRMS, FTIR, NMR.