Synthesis of 1-aroylmethylpyrroles as useful intermediates for further chemical transformation

Abstract

The synthesis of 1-aroylmethylpyrroles from 2-bromo-1-(2-aminophenyl)ethan-1-one and monodi-or tri-substituted 1H-pyrroles, has been investigated. The reactions take place at r.

Domino [4 + 2] Annulation Access to Quinone–Indolizine Hybrids: Anticancer N-Fused Polycycles

“…However, quinone–indolizine hybrid 4 has not been disclosed yet, to the best of our knowledge. As part of our continuing efforts to generate new hybrid structures, we reasoned that novel quinone–indolizine molecular hybrid structures such as 4 would be constructed via annulation of N -substituted pyrrole-2-carboxaldehydes 3 , and quinones (Scheme b). Mechanistically, we expected that the central pyridine ring would be formed by a domino Michael addition–intramolecular aldol–dehydration–aromatization procedure .…”