Synthesis of 1,5-disubstituted-4-oxo-4,5-dihydro-1 H -pyrazolo[4,3- c ]pyridine-7-carboxamides

Synthesis and preliminary biological evaluations of (+)-isocampholenic acid-derived amides

“…Following our previous successful applications of BPC as an activating agent for acids, i.e. for the formation of activated pentafluorophenyl esters for the peptide bond formation [18][19][20], 1 was treated with BPC in the presence of Et 3 N in anhydrous MeCN. The in situ formed reactive ester 11 was coupled with a variety of aliphatic amines 12a-k, thus furnishing the corresponding amides 13a-k in 59-91 % isolated yields.…”

Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents

“…Synthesis of this was achieved starting from the commercially available diethyl beta-ketoglutarate ( 29 ) and reacting with N,N -dimethylformamide dimethyl acetal ( Scheme 1 ). 20 Addition of tert -butyl 4-hydrazinopiperidine-1-carboxylate led to the pyrazole ( 31 ), which was further functionalised by refluxing with Bredereck’s reagent followed by the addition of dichlorobenzylamine. Partial cyclisation was observed at this stage, however, the crude product was fully cyclised with sodium ethoxide.…”

An Efficient One‐Pot Four‐Component Synthesis of Some New Spirooxindole Dihydropyridine Using Alum as a Heterogeneous Green Catalyst

“…There are several methods reported for the preparation of dihydropyridine [21][22][23][24][25] and spirooxindole derivatives [26][27][28][29][30][31].…”