Synthesis of 1′-(4′-Thio-β-d-Ribofuranosyl) Uracil

Chemical synthesis of 4′-thio and 4′-sulfinyl pyrimidine nucleoside analogues

“…By conducting the reaction just below the boiling point of MeCN, at 75 °C, the yield improved significantly, to 74%. The β-anomer of 13 formed preferentially ( 1 H NMR of crude 13 indicated a 10/1, β/α ratio, [ 3 J H1–H2 = 6.8 Hz for β-13 ]) and the reaction was scalable to 10 g. 25…”