Synthesis of 1,4-dihydropyridine using microwave-assisted aza-Diels–Alder reaction and its application to Amlodipine

Lee, Youn A.; Kim, Seok Chan

doi:10.1016/j.jiec.2011.02.031

Cited by 18 publications

(3 citation statements)

References 10 publications

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“…The reaction of the bromo compound with 2-azidoethanol in the presence of the sodium hydride of the compound provided 8 in two steps yields good overall results. Finally, reduction of the azido group using zinc dust to the amine was achieved to give the desired amlodipine 9 with satisfactory results 17 .…”

Section: Amlodipin Synthesismentioning

confidence: 99%

The Review: The Discovery and Development of Amlodipine Drug

Putri¹,

Mustika²,

Asra³

2022

Asian J Pharm Res Dev

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Section: Amlodipin Synthesismentioning

confidence: 99%

The Review: The Discovery and Development of Amlodipine Drug

Putri¹,

Mustika²,

Asra³

2022

Asian J Pharm Res Dev

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“…(97) were prepared by an aza-Diels-Alder [4+2] cycloaddition strategy (Scheme 2.68) promoted by MW irradiation. The 1,4-dihydropyridine prepared (97) was converted further to antihypertensive drug Amlodipine (not shown here) [105].…”

Section: Diels-alder Cycloadditionsmentioning

confidence: 99%

Microwave-Assisted Syntheses in Organic Chemistry

Kiss

Bálint²,

Keglevich

2016

SpringerBriefs in Molecular Science

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The second part focuses on the summary of typical organic chemical reactions selected, such as coupling reactions (C-C bond formation reactions, carbon-heteroatom bond formations), condensations (aldol-type-, Claisen-, Knoevenagel reaction), multicomponent reactions (Mannich-, Biginelli-, Hantzsch-, Bucherer-Bergs-, Strecker-, Gewald-, Kabachnik-Fields-, Kindler-, Passerini-, Ugi-and domino reactions), cycloadditions (including Diels-Alder reactions). The authors tried to compile fashionable reactions that have been reviewed less in the past years.

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“…A rapid synthesis of 1,4-dihydropyridine was achieved by microwave-assisted aza-Diels-Alder reaction (Lee and Kim, 2011). …”

mentioning

confidence: 99%