Synthesis of 1,3,5-trisubstituted-1,2,4-triazoles by microwave-assisted N-acylation of amide derivatives and the consecutive reaction with hydrazine hydrochlorides

Lee, Jongbok; Hong, Myengchan; Jung, Yoonchul; Cho, Eun Jin; Rhee, Hakjune

doi:10.1016/j.tet.2012.01.003

Cited by 39 publications

(38 citation statements)

References 24 publications

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“…The analysis of the above‐mentioned sources shows that the structure of triazole derivatives, namely, the nature of the groups combined with a triazole ring is of great significance. As practice shows sometimes for specific cases the development of a new method is required, which is confirmed by literary sources of recent years –…”

Section: Introductionmentioning

confidence: 79%

Synthesis, Study of the Biological Activity of New 1,2,4‐Triazole Derivatives and Characteristics of the Relationship of the Structure and Biological Activity in a Series of the Latter

et al. 2019

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Screening in a series of 1,2,4‐triazole derivatives has revealed an antinematode property in relation to positive nematodes. A certain relationship has been established between the structure and biological activity of the proposed compounds. It has been experimentally proved, that if the sulfur is present in molecules in the thionic form only, it leads to an increase in the viability of nematodes by 3–4%, and if compounds contain only the thiol form, it decreases the viability of nematodes by 20–40% depending on the concentration of the compounds used. It was also found that bis‐triazoles containing only the thiol form demonstrated antifungal activity, inhibiting the growth of C. albicans by 35–40%.

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Section: Introductionmentioning

confidence: 79%

Synthesis, Study of the Biological Activity of New 1,2,4‐Triazole Derivatives and Characteristics of the Relationship of the Structure and Biological Activity in a Series of the Latter

et al. 2019

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“…H 2 SO 4 as catalyst instead increased the yield slightly. Microwave-assisted synthesis (acid catalyst) using a procedure modified from that of Lee, et al [21], optimized for power and time, increased the yield to 18%. Infrared, mass, and 1 H NMR spectra were consistent with the published data [1].…”

Section: Di(2-thienyl)imide and Poly(di(2-thienyl)imidementioning

confidence: 99%

Synthesis and crystal structures of transition metal ion complexes of di(2-thienyl)imide

et al. 2017

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Di(2-thienyl)imide, 1, has been shown to chemically polymerize, and, if metal complexes of 1 could be synthesized, the polymer could have potential applications as an ion sensor and environmental remediation agent. As a first step towards this goal, di(2thienyl)imide is shown to form complexes with Mn (II), Co (II), and Zn (II) perchlorates. The complexes of Mn 2+ and Co 2+ are isostructural with two di(2-thienyl)imide ligands in equatorial positions and two perchlorate ions axial. The Zn 2+ complex has two water molecules in the axial positions and the thiophene rings in the two equatorial ligands are tilted in the same direction from the median plane due to intra-and intermolecular contacts. The crystal structures and infrared spectra, as well as an improved synthesis and polymerization of di(2-thienyl)imide, are reported and discussed.

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“…The mixture underwent microwave irradiation for 3 min. at 400 W according to a general procedure for N-acylation of amides which was adapted from Lee et al 36 The resulting caramel colored solution was cooled and quenched with ice water. The product mixture was extracted with dichloromethane several times.…”

Section: Synthesismentioning

confidence: 99%

Synthesis and characterization of complexes formed by transition metal ions with thiophene imides as potential precursors to metal ion uptake and release agents

Garcia

Patel

Day

et al. 2016

Inorganica Chimica Acta

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Since the starting material, 2-thiophenecarboxamide, is readily available, methyl-2thienylimide was used as the preliminary basis for our studies (scheme 3), and most of our current work has been carried out using this ligand as a test case recognizing that similar chemistry would most probably occur for the methyl-3-thienylimide. In this paper we report on the successful complexation of Mn 2+ , Co 2+ , and Ni 2+ by methyl-2-thienylimide and the complexation of Co 2+ by methyl-3-thienylimide demonstrating the feasibility of this approach. The single crystal X-ray structures as well as the infrared and visible spectra of the complexes are discussed.

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Synthesis of 1,3,5-trisubstituted-1,2,4-triazoles by microwave-assisted N-acylation of amide derivatives and the consecutive reaction with hydrazine hydrochlorides

Cited by 39 publications

References 24 publications

Synthesis, Study of the Biological Activity of New 1,2,4‐Triazole Derivatives and Characteristics of the Relationship of the Structure and Biological Activity in a Series of the Latter

Synthesis, Study of the Biological Activity of New 1,2,4‐Triazole Derivatives and Characteristics of the Relationship of the Structure and Biological Activity in a Series of the Latter

Synthesis and crystal structures of transition metal ion complexes of di(2-thienyl)imide

Synthesis and characterization of complexes formed by transition metal ions with thiophene imides as potential precursors to metal ion uptake and release agents

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