Synthesis of 1, 3, 5 Trazinane-2-ones and 1, 3, 5 Oxadiazinane-2-ones linked with Benzimidazoles

The present study is aiming at synthesis of new heterocycles like benzimidazole nucleus containing Pyrazole, isoxazole and thiazoles. The title compounds were synthesized from 4-(1H-benzo[d]imidazol-2-yl) oxazol-2-amine (1). The title compounds were evaluated for their in vitro anti-inflammatory activity and showed excellent to moderate activity and molecular docking studies were supporting anti-inflammatory activity exhibiting high inhibition constant and binding energy. The chemical structures of the synthesised compounds were characterized by IR, 1HNMR, Mass spectroscopic techniques.

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Synthesis, In-vitro and In-silico Anti-inflammatory activity of new Thiazole derivatives

Gullapelli

Maroju

Merugu

2021

RJPT

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Synthesis of 1, 3, 5 Trazinane-2-ones and 1, 3, 5 Oxadiazinane-2-ones linked with Benzimidazoles

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Synthesis, In-vitro and In-silico Anti-inflammatory activity of new Thiazole derivatives

Synthesis, In-vitro and In-silico Anti-inflammatory activity of new Thiazole derivatives

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